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121790 AGL 2043

121790
  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information
Description
Overview

This product has been discontinued.

Please refer to our complete listing of receptor tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





A cell-permeable tricyclic quinoxaline compound that acts as a potent, selective, ATP-competitive, and reversible inhibitor of type III receptor tyrosine kinases PDGFR (IC50 = 800 nM in 3T3 cells; 90 nM against purified PDGFβ-receptor), Flt3, and Kit (IC50 = 1-3 µM). A weak inhibitor of PKA, EGFR, IGF-1R, VEGFR, and Src kinases (IC50 > 30 µM). Shown to be non-toxic. Potently inhibits smooth muscle cell proliferation and balloon-induced stenosis in pig heart. Displays enhanced aqueous solubility compared with its parent compound AG 1295 (Cat. No. 658550).
Catalogue Number121790
Brand Family Calbiochem®
SynonymsTyrphostin AGL 2043, 1,2-Dimethyl-6-(2-thienyl)-imidazolo[5,4-g]quinoxaline
References
ReferencesGazit, A., et al. 2003. Bioorg. Med. Chem. 11, 2007.
Product Information
CAS number22617-28-8
FormYellow solid
Hill FormulaC₁₅H₁₂N₄S
Chemical formulaC₁₅H₁₂N₄S
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

AGL 2043 Certificates of Analysis

TitleLot Number
121790

References

Hivatkozások áttekintése
Gazit, A., et al. 2003. Bioorg. Med. Chem. 11, 2007.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2007 JSW
SynonymsTyrphostin AGL 2043, 1,2-Dimethyl-6-(2-thienyl)-imidazolo[5,4-g]quinoxaline
DescriptionA cell-permeable, tricyclic quinoxaline compound that acts as a potent, selective, ATP-competitive, and reversible inhibitor of type III receptor tyrosine kinases, PDGFR (IC50 = 800 nM in 3T3 cells; 90 nM against purified PDGFβ-receptor), Flt3, and Kit (IC50 ~1-3 µM). Weakly inhibits PKA, EGFR, IGF-1R, VEGFR, and Src kinases (IC50 > 30 µM). Shown to be non-toxic. Potently inhibits smooth muscle cell proliferation and balloon-induced stenosis in porcine heart. Displays enhanced aqueous solubility compared with its parent compound, AG 1295 (Cat. No 658550).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number22617-28-8
Chemical formulaC₁₅H₁₂N₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesGazit, A., et al. 2003. Bioorg. Med. Chem. 11, 2007.