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182200 βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem

The βARK1 Inhibitor, also referenced under CAS 24269-96-3, controls the biological activity of βARK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: β-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate

Primary Target: βARK1 (β-Adrenergic Receptor Kinase 1)
182200
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
24269-96-3C₁₂H₉NO₆

Products

KatalógusszámCsomagolás Menny./csomag
182200-5MG Muanyagampulla 5 mg
Description
OverviewA selective inhibitor of βARK1 (β-Adrenergic Receptor Kinase 1) (IC50 = 126 µM). Has no inhibitory activity against protein kinase A (PKA).
Catalogue Number182200
Brand Family Calbiochem®
Synonymsβ-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
References
ReferencesIino, M., et al. 2002. J. Med. Chem. 45, 2150.
Product Information
CAS number24269-96-3
ATP CompetitiveN
FormYellow to orange solid
Hill FormulaC₁₂H₉NO₆
Chemical formulaC₁₂H₉NO₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetβARK1 (β-Adrenergic Receptor Kinase 1)
Primary Target IC<sub>50</sub>126 µM against βARK1 (β-Adrenergic Receptor Kinase 1)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
182200-5MG 04055977205046

Documentation

βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem Certificates of Analysis

TitleLot Number
182200

References

Hivatkozások áttekintése
Iino, M., et al. 2002. J. Med. Chem. 45, 2150.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2016 JSW
Synonymsβ-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
DescriptionA selective inhibitor of β-adrenergic receptor kinase 1 (βARK1) (IC50 = 126 µM). Displays no inhibitory activity against protein kinase A (PKA). Identified from a group of existing compounds (not previously demonstrated to inhibit βARK1) using a two-step rational drug design protocol that included molecular modeling and comparative docking studies. Represents the first inhibitor that distinguishes between βARK1 and PKA, an enzyme with a similar adenine binding pocket. May be useful in the study of mechanisms involved in congestive heart failure where elevated levels of βARK1 desensitize agonist-bound β2-adrenergic receptors.
FormYellow to orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number24269-96-3
Chemical formulaC₁₂H₉NO₆
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml) or Methanol
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesIino, M., et al. 2002. J. Med. Chem. 45, 2150.