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110123 Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem

110123
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
67416-61-9C₃₂H₄₈O₅
Description
Overview

This product has been discontinued.



A cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥ 10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.

Catalogue Number110123
Brand Family Calbiochem®
SynonymsAKβBA, 3-O-Acetyl-11-keto-β-Boswellic Acid
References
ReferencesSyrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.
Product Information
CAS number67416-61-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₂H₄₈O₅
Chemical formulaC₃₂H₄₈O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-lipoxygenase
Primary Target IC<sub>50</sub>1.5 µM against 5-lipoxygenase in rat PMNLs
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem Certificates of Analysis

TitleLot Number
110123

References

Hivatkozások áttekintése
Syrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-May-2010 JSW
SynonymsAKβBA, 3-O-Acetyl-11-keto-β-Boswellic Acid
DescriptionA cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number67416-61-9
Chemical formulaC₃₂H₄₈O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesSyrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.