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119151 Adenosine A2B Receptor Antagonist I, MRS 1754 - CAS 264622-58-4 - Calbiochem

119151
  
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Áttekintés

Replacement Information
Description
Overview

This product has been discontinued.



A p-cyanoanilide xanthine derivative that acts as a highly selective, high affinity antagonist of adenosine A2B receptor (A2BR; Ki = 1.97 nM for human A2BR). Does not significantly affect other adenosine receptors (Ki = 403 nM, 503 nM, and 570 nM for human A1R, A2AR, and A3R, respectively). Exhibits some antagonist action on rat A1R (Ki = 16.8 nM). Shown to abolish the cardioprotective effects of NECA (Cat. No. 119140).

Catalogue Number119151
Brand Family Calbiochem®
Synonyms8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine, MRS-1754, MRS1754
References
ReferencesJi, X., et al. 2001. Biochem Pharmacol. 61, 657.
Philipp, S., et al. 2006. Cardiovasc Res. 70, 308.
Kim, Y. C., et al. 2000. J Med Chem. 43, 1165.
Kreckler, L. M., et al. 2006. J Pharmacol Exp Ther. 331.
Ma, D.F., et al. 2010. Hum Pathol. 41, 1550.
Product Information
CAS number264622-58-4
FormWhite solid
Hill FormulaC₂₆H₂₆N₆O₄
Chemical formulaC₂₆H₂₆N₆O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAdenosine A2B Receptor
Primary Target K<sub>i</sub>1.97 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine A2B Receptor Antagonist I, MRS 1754 - CAS 264622-58-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Adenosine A2B Receptor Antagonist I, MRS 1754 - CAS 264622-58-4 - Calbiochem Certificates of Analysis

TitleLot Number
119151

References

Hivatkozások áttekintése
Ji, X., et al. 2001. Biochem Pharmacol. 61, 657.
Philipp, S., et al. 2006. Cardiovasc Res. 70, 308.
Kim, Y. C., et al. 2000. J Med Chem. 43, 1165.
Kreckler, L. M., et al. 2006. J Pharmacol Exp Ther. 331.
Ma, D.F., et al. 2010. Hum Pathol. 41, 1550.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2013 JSW
Synonyms8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine, MRS-1754, MRS1754
DescriptionA p-cyanoanilide xanthine derivative that acts as a highly selective, high affinity antagonist of adenosine A2B receptor (A2BR; Ki = 1.97 nM for human A2BR). Does not significantly affect other adenosine receptors (Ki = 403 nM, 503 nM, and 570 nM for human A1R, A2AR, and A3R, respectively). Exhibits some antagonist action on rat A1R (Ki = 16.8 nM). Shown to abolish the cardioprotective effects of NECA (Cat. No. 119140).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number264622-58-4
Chemical formulaC₂₆H₂₆N₆O₄
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJi, X., et al. 2001. Biochem Pharmacol. 61, 657.
Philipp, S., et al. 2006. Cardiovasc Res. 70, 308.
Kim, Y. C., et al. 2000. J Med Chem. 43, 1165.
Kreckler, L. M., et al. 2006. J Pharmacol Exp Ther. 331.
Ma, D.F., et al. 2010. Hum Pathol. 41, 1550.