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116845 Adenylyl Cyclase Toxins Inhibitor

116845
  
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Áttekintés

Replacement Information
Description
Overview

This product has been discontinued.

We apologize for the inconvenience, but we do not currently have an alternative product. For related products, please refer to our complete listing of adenylate cyclase inhibitors.





A cell-permeable quinazoline compound that mimics adenine and acts as a specific, ATP-competitive (Ki ~ 20 µM) inhibitor of EF (edema factor) and CyaA adenylyl cyclase (AC) activities (IC50 = 90 µM). Does not inhibit EF-CaM (calmodulin) interaction or mammalian AC type I, II and V activities.
Catalogue Number116845
Brand Family Calbiochem®
SynonymsEthyl-5-aminopyrazolo[1,5-a]quinazoline-3-carboxylate
References
ReferencesSoelaiman, S., et al. 2003. J. Biol. Chem. 278, 25990.
Product Information
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₃H₁₂N₄O₂
Chemical formulaC₁₃H₁₂N₄O₂
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetEF (edema factor) and CyaA adenylyl cyclase (AC) activities
Primary Target IC<sub>50</sub>90 *micro;M
Secondary targetATP-competitive (Ki ~ 20 µM)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adenylyl Cyclase Toxins Inhibitor Certificates of Analysis

TitleLot Number
116845

References

Hivatkozások áttekintése
Soelaiman, S., et al. 2003. J. Biol. Chem. 278, 25990.

Data Sheet

Title
Data Sheet -116845
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
SynonymsEthyl-5-aminopyrazolo[1,5-a]quinazoline-3-carboxylate
DescriptionA cell-permeable quinazoline compound that mimics adenine and acts as a specific, ATP-competitive (Ki ~20 µM) inhibitor of edema factor (EF) and CyaA adenylyl cyclase (AC) (IC50 = 80 µM) activities. Does not inhibit EF-calmodulin interaction or the activities of mammalian AC types I, II, or V.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃H₁₂N₄O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSoelaiman, S., et al. 2003. J. Biol. Chem. 278, 25990.