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124019 Akt Inhibitor IX, API-59CJ-OMe - CAS 98510-80-6 - Calbiochem

124019
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
98510-80-6C₂₁H₂₂N₂O₃ • 3H₂O
Description
OverviewA cell-permeable ellipticine compound that potently and selectively induces apoptosis in human endometrial cancer cells (RL95-2 and Ishikawa) that exhibit elevated Akt activity (effective concentration = 12-24 µM), but not on cells with low Akt activity. Directly affects the activity by Akt, but not the level of cellular phosphorylation of Akt, ERK1/2, JNK1/2, PDK1, PKC isoforms, or serum and glucocorticoid-inducible kinase (SGK).
Catalogue Number124019
Brand Family Calbiochem®
SynonymsMMEA, 9-Methoxy-2-methylellipticinium acetate, NSC 627505
References
ReferencesJin, X., et al. 2004. Br. J. Cancer 91, 1808.
Product Information
CAS number98510-80-6
ATP CompetitiveN
FormOrange red solid
Hill FormulaC₂₁H₂₂N₂O₃ • 3H₂O
Chemical formulaC₂₁H₂₂N₂O₃ • 3H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAkt
Primary Target IC<sub>50</sub>12-24 µM against Akt
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Akt Inhibitor IX, API-59CJ-OMe - CAS 98510-80-6 - Calbiochem Certificates of Analysis

TitleLot Number
124019

References

Hivatkozások áttekintése
Jin, X., et al. 2004. Br. J. Cancer 91, 1808.

Brochure

Title
Akt
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
SynonymsMMEA, 9-Methoxy-2-methylellipticinium acetate, NSC 627505
DescriptionA cell-permeable ellipticine compound that potently and selectively induces apoptosis in human endometrial cancer cells (RL95-2 and Ishikawa) that exhibit elevated Akt activity (effective concentration = 12-24 µM), but not on cells with low Akt activity. Directly affects the activity by Akt, but not the level of cellular phosphorylation of Akt, ERK1/2, JNK1/2, PDK1, PKC isoforms, or serum and glucocorticoid-inducible kinase (SGK).
FormOrange red solid
Intert gas (Yes/No) Packaged under inert gas
CAS number98510-80-6
Chemical formulaC₂₁H₂₂N₂O₃ • 3H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesJin, X., et al. 2004. Br. J. Cancer 91, 1808.