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124028 Akt Inhibitor XI - Calbiochem

124028
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₁₁H₉Cl₂CuN₃O₂S
Description
Overview

This product has been discontinued.



A cell-permeable copper complex (Cu2+/Cu+ redox couple in the range of +0.28 to +0.35 V) that interacts with both the PH and the kinase domains of Akt and potently inhibits its kinase activity (IC50 = 100 nM). Inhibits tumor growth both in cultured cells in vitro (IC50 ranges from 10 to 34 µM) and in mice in vivo (25 mg/kg, iv) without any apparent adverse effect to the animals.

Catalogue Number124028
Brand Family Calbiochem®
Synonyms3-Formylchromone thiosemicarbazone, Cu(II)Cl₂ Complex, FPA-124
References
ReferencesBarve, V., et al. 2006. J. Med. Chem. 49, 3800.
Product Information
ATP CompetitiveN
FormGreen solid
Hill FormulaC₁₁H₉Cl₂CuN₃O₂S
Chemical formulaC₁₁H₉Cl₂CuN₃O₂S
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetAkt
Primary Target IC<sub>50</sub>100 nM against Akt
Purity≥98% by Elemental Analysis
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Akt Inhibitor XI - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Akt Inhibitor XI - Calbiochem Certificates of Analysis

TitleLot Number
124028

References

Hivatkozások áttekintése
Barve, V., et al. 2006. J. Med. Chem. 49, 3800.

Brochure

Title
Akt
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-April-2008 RFH
Synonyms3-Formylchromone thiosemicarbazone, Cu(II)Cl₂ Complex, FPA-124
DescriptionA cell-permeable copper complex (Cu2+/Cu+ redox couple in the range of +0.28 to +0.35 V) that interacts with both the PH and the kinase domains of Akt and potently inhibits its kinase activity (IC50 = 100 nM). Inhibits tumor growth both in cultured cells in vitro (IC50 ranges from 10 to 34 µM) and in mice in vivo (25 mg/kg, iv) without any apparent adverse effect to the animals.
FormGreen solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₁H₉Cl₂CuN₃O₂S
Structure formulaStructure formula
Purity≥98% by Elemental Analysis
SolubilityH₂O (5 mg/ml) or DMSO (2 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesBarve, V., et al. 2006. J. Med. Chem. 49, 3800.