Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

176700 Angiostatin® Protein, Human

176700
  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information
Description
Overview

This product has been discontinued.

We are offering Angiostatin K1-3, Human, Recombinant, P. pastoris (Cat. No. 176708) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






A proteolytic fragment of plasminogen constituting kringles 1 - 4. A specific inhibitor of endothelial cell proliferation and one of the most potent and specific natural inhibitors of angiogenesis and metastatic tumor growth. Human angiostatin significantly inhibits bFGF-induced endothelial cell proliferation and migration at concentrations ranging from 300 nM - 1.0 µM.
Catalogue Number176700
Brand Family Calbiochem®
References
ReferencesCao, Y. 1999. Haematologica 84, 643. Sim, B.K., et al. 1997. Cancer Res. 57, 1329. Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651. Cao, Y., et al. 1996. J. Biol. Chem. 271, 29461. O’Reilly, M.S., et al. 1994. Cell 79, 315.
Product Information
CAS number86090-08-6
DeclarationSold under license of U.S. Patent 6,024,688 and corresponding patents.
FormLyophilized
FormulationLyophilized from 40 mM NaCl, 20 mM HEPES-NaOH, pH 8.0.
Applications
Biological Information
Purity≥98% by SDS-PAGE (migrates as a doublet)
SourcePrepared from fluid that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Physicochemical Information
Contaminantsplasmin, plasminogen: none detected
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSBW2140000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage DEEP FREEZE (-70°C)
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Angiostatin® Protein, Human Certificates of Analysis

TitleLot Number
176700

References

Hivatkozások áttekintése
Cao, Y. 1999. Haematologica 84, 643. Sim, B.K., et al. 1997. Cancer Res. 57, 1329. Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651. Cao, Y., et al. 1996. J. Biol. Chem. 271, 29461. O’Reilly, M.S., et al. 1994. Cell 79, 315.