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119117 Anti-A1 Adenosine Receptor (309-326) Rabbit pAb

119117
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Host
Rb
Description
Overview

This product has been discontinued.





Recognizes the ~36-40 kDa G-protein-coupled A1AR in human and rat brain, spinal cord, white adipocytes, kidney, and testis.
  • Antibody Target Gene Symbol: ADORA1
  • Target Synonym: A1 ADENOSINE RECEPTOR, A1-AR, A1R, AA1R, Ad1, ADENOSINE A1 RECEPTOR, AI848715, BB176431, RDC7, Ri
  • Entrez Gene Name: adenosine A1 receptor
  • Hu Entrez ID: 134 (Related Antibodies: PC158)
  • Mu Entrez ID: 11539
  • Rat Entrez ID: 29290
  • Catalogue Number119117
    Brand Family Calbiochem®
    SynonymsAnti-A1AR
    References
    ReferencesJohnston, J.B., et al. 2001. Annu. Neurol. 49(5), 650.
    Olah, M.E., and Stiles, G.L. 2000. Pharmacol. Ther. 85(2), 55.
    Product Information
    FormLiquid
    FormulationIn PBS, 1 mg/ml BSA.
    Positive controlHuman and rat brain, spinal cord, white adipocytes, kidney or testis
    Preservative≤ 0.1% sodium azide
    Applications
    Key Applications Immunoblotting (Western Blotting)
    Immunohistochemistry
    Immunoprecipitation
    Application NotesImmunoblotting (1:1,000)
    Immunohistochemistry (1:100)
    Immunoprecipitation (see comments)
    Application CommentsWeakly cross-reacts with bovine A1AR in immunoblots. This antibody is also reported to work for immunoprecipitation. Variables associated with assay conditions will dictate the optimal working dilution.
    Biological Information
    Immunogena synthetic peptide (CQPKPPIDEDLPEEKAED) corresponding to amino acids 309-326 of rat adenosine receptor subtype A1 (A1AR)
    ImmunogenRat
    HostRabbit
    IsotypeIgG
    Physicochemical Information
    Dimensions
    Materials Information
    Toxicological Information
    Safety Information according to GHS
    Safety Information
    Product Usage Statements
    Storage and Shipping Information
    Ship Code Dry Ice Only
    Toxicity Standard Handling
    Storage -20°C
    Avoid freeze/thaw Avoid freeze/thaw
    Do not freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Packaging Information
    Transport Information
    Supplemental Information
    Specifications

    Documentation

    Anti-A1 Adenosine Receptor (309-326) Rabbit pAb Certificates of Analysis

    TitleLot Number
    119117

    References

    Hivatkozások áttekintése
    Johnston, J.B., et al. 2001. Annu. Neurol. 49(5), 650.
    Olah, M.E., and Stiles, G.L. 2000. Pharmacol. Ther. 85(2), 55.

    Brochure

    Title
    Antibody Sourcebookル Sixth Edition
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision17-July-2007 RFH
    SynonymsAnti-A1AR
    ApplicationImmunoblotting (1:1,000)
    Immunohistochemistry (1:100)
    Immunoprecipitation (see comments)
    DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the 36-40 kDa A1AR protein.
    BackgroundAdenosine produces a wide variety of physiological effects through the activation of cell surface adenosine receptors (ARs). ARs are members of the G-protein-coupled receptor family, and currently, four subtypes, the A1AR, A2AAR, A2BAR, and A3AR, are recognized. The A1AR is a glycoprotein (36-40 kDa) that can activate Gi and Go proteins in vitro. A1AR is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. It has been reported that adenosine A1 receptor (A1AR) regulates tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6) expression and exhibits diminished function in patients with multiple sclerosis. Other tissues also express A1AR, including kidney and testis.
    HostRabbit
    Immunogen speciesRat
    Immunogena synthetic peptide (CQPKPPIDEDLPEEKAED) corresponding to amino acids 309-326 of rat adenosine receptor subtype A1 (A1AR)
    IsotypeIgG
    Speciesbovine (weakly), human, rat
    Positive controlHuman and rat brain, spinal cord, white adipocytes, kidney or testis
    FormLiquid
    FormulationIn PBS, 1 mg/ml BSA.
    Preservative≤ 0.1% sodium azide
    CommentsWeakly cross-reacts with bovine A1AR in immunoblots. This antibody is also reported to work for immunoprecipitation. Variables associated with assay conditions will dictate the optimal working dilution.
    Storage Avoid freeze/thaw
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Standard Handling
    ReferencesJohnston, J.B., et al. 2001. Annu. Neurol. 49(5), 650.
    Olah, M.E., and Stiles, G.L. 2000. Pharmacol. Ther. 85(2), 55.