233170 Anti-CLOCK (11-30) Rabbit pAb

233170
  
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      Áttekintés

      Replacement Information

      Kulcsspecifikációk táblázata

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~100 kDa CLOCK protein.
      Catalogue Number233170
      Brand Family Calbiochem®
      References
      ReferencesKing, D.P. and Takahashi, J.S. 2000. Annu. Rev. Neurosci. 23, 713.
      Darlington, T.K, et al. 1998. Science 280, 1599.
      Gekakis, N., et al. 1998. Science 280, 1564.
      Product Information
      FormLiquid
      FormulationIn PBS, BSA.
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Immunohistochemistry
      Application NotesImmunoblotting (1:200)
      Immunohistochemistry (1:1000)
      Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogena synthetic peptide [SSIVDRDDSSIFDGLVEEDD(C)] corresponding to amino acids 11-30 of the human and mouse CLOCK protein
      ImmunogenHuman and Mouse
      HostRabbit
      IsotypeIgG
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-CLOCK (11-30) Rabbit pAb Certificates of Analysis

      TitleLot Number
      233170

      References

      Hivatkozások áttekintése
      King, D.P. and Takahashi, J.S. 2000. Annu. Rev. Neurosci. 23, 713.
      Darlington, T.K, et al. 1998. Science 280, 1599.
      Gekakis, N., et al. 1998. Science 280, 1564.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2007 RFH
      ApplicationImmunoblotting (1:200)
      Immunohistochemistry (1:1000)
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~100 kDa CLOCK protein.
      BackgroundRegulation of circadian rhythmicity is regulated at the genetic level by a protein-mediated autoregulatory feedback loop. In mammals, several genes that encode members of the basic helix-loop-helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila, PER. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL transactivation complex.
      HostRabbit
      Immunogen speciesHuman and Mouse
      Immunogena synthetic peptide [SSIVDRDDSSIFDGLVEEDD(C)] corresponding to amino acids 11-30 of the human and mouse CLOCK protein
      IsotypeIgG
      Specieshamster, human, mouse, rat
      FormLiquid
      FormulationIn PBS, BSA.
      Preservative≤0.1% sodium azide
      CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Storage -20°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesKing, D.P. and Takahashi, J.S. 2000. Annu. Rev. Neurosci. 23, 713.
      Darlington, T.K, et al. 1998. Science 280, 1599.
      Gekakis, N., et al. 1998. Science 280, 1564.