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178492 Apoptosis Activator II

178492
  
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      Áttekintés

      Replacement Information

      Kulcsspecifikációk táblázata

      Empirical Formula
      C₁₅H₉Cl₂NO₂
      Description
      Overview

      This product has been discontinued.





      A cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 µM for Jurkat, Molt-4, and CCRF-CEM) and shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1.
      Catalogue Number178492
      Brand Family Calbiochem®
      Synonyms1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione
      References
      ReferencesNguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.
      Product Information
      CAS number79183-19-0
      FormOrange solid
      Hill FormulaC₁₅H₉Cl₂NO₂
      Chemical formulaC₁₅H₉Cl₂NO₂
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Apoptosis Activator II Certificates of Analysis

      TitleLot Number
      178492

      References

      Hivatkozások áttekintése
      Nguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      Synonyms1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione
      DescriptionA cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner. Shown to induce apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Cytotoxicity is reported to be selective for tumor cells (IC50 <10 µM for Jurkat, Molt-4, and CCRF-CEM cells). Exhibits little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number79183-19-0
      Chemical formulaC₁₅H₉Cl₂NO₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.