216201 Carboxyatractyloside, Potassium Salt, Xanthium sibiricum - CAS 35988-42-2 - Calbiochem

216201
  
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      Empirical FormulaCAS #
      C₃₁H₄₃O₁₈S₂K₃•3H₂O 35988-42-2
      Description
      Overview

      This product has been discontinued.



      We are offering Carboxyatractyloside potassium salt (Cat. No. C4992) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






      Toxic compound isolated from the plant Xanthium sibiricum. A highly selective and potent inhibitor of adenine nucleotide translocator (ANT) (Ki < 10 nM) and inducer of permeability transition pore opening. Stabilizes the nucleoside binding site of ANT on the cytoplasmic side of the inner membrane and blocks the exchange of matrix ATP and cytoplasmic ADP. Does not affect the activity of mitochondrial multiple conductance channel (MCC).

      CAS No. refers to that of the free acid.
      Catalogue Number216201
      Brand Family Calbiochem®
      SynonymsC-ATR, CAT
      References
      ReferencesPebay-Peyroula, E., et al. 2003. Nature 426, 39.
      Huber, T., et al. 1999. Biochemistry 38, 762.
      Fiore, C., et al. 1998. Biochimie 80, 137.
      Lohret, T.A., et al. 1996. J. Biol. Chem. 271, 4846.
      Product Information
      CAS number35988-42-2
      FormWhite solid
      Hill FormulaC₃₁H₄₃O₁₈S₂K₃•3H₂O
      Chemical formulaC₃₁H₄₃O₁₈S₂K₃•3H₂O
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37-45

      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Moisture Protect from moisture
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      216201

      References

      Hivatkozások áttekintése
      Pebay-Peyroula, E., et al. 2003. Nature 426, 39.
      Huber, T., et al. 1999. Biochemistry 38, 762.
      Fiore, C., et al. 1998. Biochimie 80, 137.
      Lohret, T.A., et al. 1996. J. Biol. Chem. 271, 4846.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-November-2008 RFH
      SynonymsC-ATR, CAT
      DescriptionToxic compound isolated from the plant Xanthium sibiricum. A highly selective and potent inhibitor of adenine nucleotide translocator (ANT) (Ki <10 nM) and inducer of permeability transition pore opening. Stabilizes the nucleoside binding site of ANT on the cytoplasmic side of the inner membrane and blocks the exchange of matrix ATP and cytoplasmic ADP. Does not affect the activity of mitochondrial multiple conductance channel (MCC). CAS No. refers to that of the free acid.
      FormWhite solid
      CAS number35988-42-2
      Chemical formulaC₃₁H₄₃O₁₈S₂K₃•3H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesPebay-Peyroula, E., et al. 2003. Nature 426, 39.
      Huber, T., et al. 1999. Biochemistry 38, 762.
      Fiore, C., et al. 1998. Biochimie 80, 137.
      Lohret, T.A., et al. 1996. J. Biol. Chem. 271, 4846.