218717 Casein Kinase II Inhibitor V, Quinalizarin - CAS 81-61-8 - Calbiochem

218717
  
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      Áttekintés

      Replacement Information

      Kulcsspecifikációk táblázata

      Empirical FormulaCAS #
      C₁₄H₈O₆ 81-61-8
      Description
      Overview

      This product has been discontinued.



      A cell-permeable hydroxylated anthraquinone compound that acts as a potent (IC50 = 110 nM), highly selective (IC50 >1µM against CK1 and 83 other kinases), and ATP-competitive (Ki = 50 nM) CK2 inhibitor with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against DYRK1a, PIM1/3, and HIPK2. Quinalizarin is about 4.3- and 1.9-fold more effective than TBB, respectively, in cellular CK2 activity inhibition and in apoptosis induction in Jurkat cell cultures.

      Catalogue Number218717
      Brand Family Calbiochem®
      Synonyms1,2,5,8-Tetrahydroxy-9,10-anthraquinone
      References
      ReferencesCozza, G., et al. 2009. Biochem. J. 421, 387.
      Product Information
      CAS number81-61-8
      FormDark red solid
      Hill FormulaC₁₄H₈O₆
      Chemical formulaC₁₄H₈O₆
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Casein Kinase II Inhibitor V, Quinalizarin - CAS 81-61-8 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Casein Kinase II Inhibitor V, Quinalizarin - CAS 81-61-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      218717

      References

      Hivatkozások áttekintése
      Cozza, G., et al. 2009. Biochem. J. 421, 387.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-June-2010 RFH
      Synonyms1,2,5,8-Tetrahydroxy-9,10-anthraquinone
      DescriptionA cell-permeable hydroxylated anthraquinone compound that acts as a potent (IC50 = 110 nM), highly selective (IC50 >1µM against CK1 and 83 other kinases), and ATP-competitive (Ki = 50 nM) CK2 inhibitor with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against DYRK1a, PIM1/3, and HIPK2. Quinalizarin is about 4.3- and 1.9-fold more effective than TBB, respectively, in cellular CK2 activity inhibition and in apoptosis induction in Jurkat cell cultures.
      FormDark red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number81-61-8
      Chemical formulaC₁₄H₈O₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesCozza, G., et al. 2009. Biochem. J. 421, 387.