218729 Caspase Inhibitor VIII

218729
  
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      Áttekintés

      Replacement Information

      Kulcsspecifikációk táblázata

      Empirical Formula
      C₂₃H₃₇N₅O₁₀
      Description
      Overview

      This product has been discontinued.





      A potent, reversible inhibitor of caspase-2 (Ki = 3.5 nM), caspase-3 (Ki = 1 nM) and caspase-7 (Ki = 7.5 nM). Also serves as an inhibitor of DRONC (Drosophila caspase), a glutamate/aspartate protease.
      Catalogue Number218729
      Brand Family Calbiochem®
      SynonymsAc-VDVAD-CHO
      References
      ReferencesDorstyn, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4307.
      Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
      Product Information
      ATP CompetitiveN
      FormOff-white lyophilized solid
      Hill FormulaC₂₃H₃₇N₅O₁₀
      Chemical formulaC₂₃H₃₇N₅O₁₀
      ReversibleY
      Applications
      Biological Information
      Primary Targetcaspase-2
      Primary Target K<sub>i</sub>3.5 nM, 1 nM, 7.5 nM, against caspase-2, caspase-3. and caspase-7, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Val-Asp-Val-Ala-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase Inhibitor VIII Certificates of Analysis

      TitleLot Number
      218729

      References

      Hivatkozások áttekintése
      Dorstyn, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4307.
      Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Titulus
    • Zhonghua Gao, Yufang Shao and Xuejun Jiang. (2005) Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. Journal of Biological Chemistry 280, 38271-38275.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-June-2008 RFH
      SynonymsAc-VDVAD-CHO
      DescriptionA potent, reversible inhibitor of caspase-2 (Ki = 3.5 nM), caspase-3 (Ki = 1.0 nM), and caspase-7 (Ki = 7.5 nM). Also serves as an inhibitor of DRONC (Drosophilia caspase), an ecdysone-inducible glutamate/aspartate caspase. Recommended for use with cells extracts and purified caspases.
      FormOff-white lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₃₇N₅O₁₀
      Peptide SequenceAc-Val-Asp-Val-Ala-Asp-CHO
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDorstyn, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4307.
      Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
      Citation
    • Zhonghua Gao, Yufang Shao and Xuejun Jiang. (2005) Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. Journal of Biological Chemistry 280, 38271-38275.