219433 Cathepsin L Inhibitor IV - Calbiochem

219433
Árak és elérhetőség megtekintése

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₂₇H₂₉N₃O₄S

Árak és elérhetőség

Katalógusszám ElérhetőségCsomagolás Menny./csomag Ár Mennyiség
219433-1MG
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      Muanyagampulla 1 mg
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      Árajánlat kérése
      Description
      OverviewA potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Also inhibits the release of Ca2+ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
      Catalogue Number219433
      Brand Family Calbiochem®
      Synonyms1-Naphthalenesulfonyl-IW-CHO
      References
      ReferencesYasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
      Product Information
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₇H₂₉N₃O₄S
      Chemical formulaC₂₇H₂₉N₃O₄S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin L
      Primary Target IC<sub>50</sub>1.9 nM against Cathepsin L
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide Sequence1-Naphthalenesulfonyl-Ile-Trp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cathepsin L Inhibitor IV - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Cathepsin L Inhibitor IV - Calbiochem Certificates of Analysis

      TitleLot Number
      219433

      References

      Hivatkozások áttekintése
      Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

      Citations

      Titulus
    • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-January-2019 JSW
      Synonyms1-Naphthalenesulfonyl-IW-CHO
      DescriptionA potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Inhibits the release of Ca2+ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
      FormWhite to off-white solid
      Chemical formulaC₂₇H₂₉N₃O₄S
      Peptide Sequence1-Naphthalenesulfonyl-Ile-Trp-CHO
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
      Citation
    • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.