235035 Coronavirus Main Proteinase Inhibitor

235035
  
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      Áttekintés

      Replacement Information
      Description
      OverviewA hexapeptidyl chloromethyl ketone that acts as an irreversible substrate-analog inhibitor of several viral proteinases. Shown to covalently modify the active site cysteine residue. The peptide is derived from the P6 - P1 residues of the NH2-terminal autoprocessing site of porcine TGEV Mpro (transmissible gastroenteritis virus main proteinase) and is expected to bind to all other coronavirus homologs, such as human SARS-CoV Mpro and HCoV 229E Mpro, in a similar manner and with similar affinity.
      Catalogue Number235035
      Brand Family Calbiochem®
      SynonymsCoV Mpro Inhibitor, 3CLpro Inhibitor, Cbz-VNSTLQ-CMK
      References
      ReferencesAnand, K., et al. 2003. Science 300, 1763.
      Product Information
      FormWhite solid
      Hill FormulaC₃₆H₅₅ClN₈O₁₂
      Chemical formulaC₃₆H₅₅ClN₈O₁₂
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceZ-Val-Asn-Ser-Thr-Leu-Gln-CMK
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Coronavirus Main Proteinase Inhibitor Certificates of Analysis

      TitleLot Number
      235035

      References

      Hivatkozások áttekintése
      Anand, K., et al. 2003. Science 300, 1763.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-June-2008 RFH
      SynonymsCoV Mpro Inhibitor, 3CLpro Inhibitor, Cbz-VNSTLQ-CMK
      DescriptionA hexapeptidyl chloromethyl ketone that acts as an irreversible substrate-analog inhibitor of several viral proteinases. Shown to covalently modify the active site cysteine residue. The peptide is derived from the P6 - P1 residues of the NH2-terminal autoprocessing site of porcine TGEV Mpro (transmissible gastroenteritis virus main proteinase) and is expected to bind to all other coronavirus homologs, such as human SARS-CoV Mpro and HCoV 229E Mpro, in a similar manner and with similar affinity.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₆H₅₅ClN₈O₁₂
      Peptide SequenceZ-Val-Asn-Ser-Thr-Leu-Gln-CMK
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage -20°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesAnand, K., et al. 2003. Science 300, 1763.