233612 Crosstide

233612
  
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      Áttekintés

      Replacement Information
      Description
      OverviewA peptide analog of GSK-3 (glycogen synthase kinase-3) that functions as a natural substrate for Akt (protein kinase B), in the presence of ATP. Displays similar specificities towards PKBα, PKBβ and PKBγ isoforms (Km = 4 µM). Also recognized by MAPKAP kinase-1 and p70S6K.
      Catalogue Number233612
      Brand Family Calbiochem®
      SynonymsGRPRTSSFAEG
      References
      ReferencesDai, F., et al. 2002. Biochem. Biophys. Res. Commun. 293, 1191. Taylor, V., et al. 2000. Mol. Cell Biol. 20, 6860. Walker, K.S., et al. 1998. Biochem. J. 331, 299. Meier, R., et al. 1997. J. Biol. Chem. 272, 30491. Cross, D.A.E., et al. 1995. Nature 378, 785. Sutherland, C., and Cohen, P. 1994. FEBS Lett. 338, 37.
      Product Information
      FormWhite lyophilized powder
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₄₈H₇₇N₁₇O₁₇
      Chemical formulaC₄₈H₇₇N₁₇O₁₇
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Peptide SequenceH-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Crosstide Certificates of Analysis

      TitleLot Number
      233612

      References

      Hivatkozások áttekintése
      Dai, F., et al. 2002. Biochem. Biophys. Res. Commun. 293, 1191. Taylor, V., et al. 2000. Mol. Cell Biol. 20, 6860. Walker, K.S., et al. 1998. Biochem. J. 331, 299. Meier, R., et al. 1997. J. Biol. Chem. 272, 30491. Cross, D.A.E., et al. 1995. Nature 378, 785. Sutherland, C., and Cohen, P. 1994. FEBS Lett. 338, 37.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-June-2008 RFH
      SynonymsGRPRTSSFAEG
      DescriptionA peptide derived from the N-terminus of glycogen synthase kinase-3 (GSK-3) that represents the sequence surrounding the serine residues (Ser21 in GSK-3α and Ser9 in GSK-3β) that are phosphorylated in vivo by MAP kinase activated protein kinase-1 (MAPKAP kinase-1) and p70 ribosomal S6 kinase (p70S6k). Functions as a natural substrate for Akt (protein kinase B) in the presence of ATP. Displays similar specificities for PKBα, PKBβ, and PKBγ (Km = 4 µM). Also serves as a substrate for MAPKAP kinase-1, p70S6k, and serum and glucocorticoid-inducible kinase-like kinase (SGKL) in in vitro kinase assays.
      FormWhite lyophilized powder
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₈H₇₇N₁₇O₁₇
      Peptide SequenceH-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDai, F., et al. 2002. Biochem. Biophys. Res. Commun. 293, 1191. Taylor, V., et al. 2000. Mol. Cell Biol. 20, 6860. Walker, K.S., et al. 1998. Biochem. J. 331, 299. Meier, R., et al. 1997. J. Biol. Chem. 272, 30491. Cross, D.A.E., et al. 1995. Nature 378, 785. Sutherland, C., and Cohen, P. 1994. FEBS Lett. 338, 37.