324833 EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem

324833
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Replacement Information

Kulcsspecifikációk táblázata

Empirical FormulaCAS #
C₁₆H₁₀Cl₃FN₄O 733009-42-2

Árak és elérhetőség

Katalógusszám ElérhetőségCsomagolás Menny./csomag Ár Mennyiség
324833-5MG
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      Üvegpalack 5 mg
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      Megrendelés befejezésekor További információ
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      Árajánlat kérése
      Description
      OverviewA cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.
      Catalogue Number324833
      Brand Family Calbiochem®
      SynonymsN-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
      References
      ReferencesShushan, A., et al. 2007. Fertil. Steril. 87, 127.
      Product Information
      CAS number733009-42-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₆H₁₀Cl₃FN₄O
      Chemical formulaC₁₆H₁₀Cl₃FN₄O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>0.7 µM and 1.1 µM suppressesing leiomyoma and myometrical cell proliferation, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      324833

      References

      Hivatkozások áttekintése
      Shushan, A., et al. 2007. Fertil. Steril. 87, 127.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2011 RFH
      SynonymsN-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
      DescriptionA cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number733009-42-2
      Chemical formulaC₁₆H₁₀Cl₃FN₄O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml). Use fresh, anhydrous DMSO.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesShushan, A., et al. 2007. Fertil. Steril. 87, 127.