341207 ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

341207
Árak és elérhetőség megtekintése

Áttekintés

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Kulcsspecifikációk táblázata

Empirical FormulaCAS #
C₂₇H₅₈NO₆P 70641-51-9

Árak és elérhetőség

Katalógusszám ElérhetőségCsomagolás Menny./csomag Ár Mennyiség
341207-50MG
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      Muanyagampulla 50 mg
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      Megrendelés befejezésekor További információ
      Elmentette a ()-t
       
      Árajánlat kérése
      341207-5MG
      Elérhetőség betöltése...
      Korlátozott elérhetőségKorlátozott elérhetőség
      Készleten 
      Megszűnt
      Korlátozott mennyiségben elérhető
      Az elérhetőség megerősítésre vár
        Remaining : Will advise
          Remaining : Will advise
          Tanácsadás
          Lépjen kapcsolatba a vevőszolgálattal
          Contact Customer Service

          Muanyagampulla 5 mg
          Az ár letöltése folyamatban...
          Az ár nem tölthető be
          Minimum Quantity needs to be mulitiple of
          Megrendelés befejezésekor További információ
          Elmentette a ()-t
           
          Árajánlat kérése
          Description
          OverviewA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
          Catalogue Number341207
          Brand Family Calbiochem®
          SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
          References
          ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
          Product Information
          CAS number70641-51-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₇H₅₈NO₆P
          Chemical formulaC₂₇H₅₈NO₆P
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPI-PLC
          Primary Target IC<sub>50</sub>9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYK0718000
          Safety Information
          R PhraseR: 40

          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          341207

          References

          Hivatkozások áttekintése
          Harguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-May-2011 JSW
          SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
          DescriptionA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Inhibits protein kinase C from various leukemic cells. Also promotes rapid and selective apoptosis in human leukemic cells. Has strong antitumor and anticancer properties.
          FormWhite solid
          CAS number70641-51-9
          RTECSYK0718000
          Chemical formulaC₂₇H₅₈NO₆P
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMSO (5 mg/ml), CHCl₃ (50 mg/ml), Ethanol (5 mg/ml), or H₂O. Material may form micelles in aqueous stock solutions, which may affect experimental results.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
          Toxicity Carcinogenic / Teratogenic
          ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.