324631 Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem

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      Empirical FormulaCAS #
      C₁₆H₁₂F₃NO 912953-25-4
      Description
      Overview

      This product has been discontinued.



      A cell-permeable quinolinone compound that acts as a highly potent and selective Eg5/KSP inhibitor (Ki = 1.4, 2.1, 2.2, and 1.7 nM for the mutant A133D, KHC-L5, D130V, and the wild-type KSP, respectively) by antagonizing ATP binding via an allosteric site. Effectively induces monopolar spindles in ovarian adenocarcinoma SKOV3 cells and inhibits the proliferation of colorectal carcinoma HCT116 cells (IC50 = 36 and 0.5 nM againt the parental and the ispinesib-resistant D130V mutant line, respectively). It is uncompetitive with respect to microtubule and exhibits little activity against a panel of 7 other mitotic kinesins.

      Catalogue Number324631
      Brand Family Calbiochem®
      SynonymsKSP Inhibitor VII; 6-(4-Trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-quinolinone, GSK-1
      References
      ReferencesLuo, L., et al. 2007. Nat. Chem. Biol. 3, 722.
      Product Information
      CAS number912953-25-4
      FormOff-white powder
      Hill FormulaC₁₆H₁₂F₃NO
      Chemical formulaC₁₆H₁₂F₃NO
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      324631

      References

      Hivatkozások áttekintése
      Luo, L., et al. 2007. Nat. Chem. Biol. 3, 722.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2011 RFH
      SynonymsKSP Inhibitor VII; 6-(4-Trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-quinolinone, GSK-1
      DescriptionA cell-permeable quinolinone compound that acts as a highly potent and selective Eg5/KSP inhibitor (Ki = 1.4, 2.1, 2.2, and 1.7 nM for the mutant A133D, KHC-L5, D130V, and the wild-type KSP, respectively) by antagonizing ATP binding via an allosteric site. Effectively induces monopolar spindles in ovarian adenocarcinoma SKOV3 cells and inhibits the proliferation of colorectal carcinoma HCT116 cells (IC50 = 36 and 0.5 nM againt the parental and the ispinesib-resistant D130V mutant line, respectively). It is uncompetitive with respect to microtubule and exhibits little activity against a panel of 7 other mitotic kinesins.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number912953-25-4
      Chemical formulaC₁₆H₁₂F₃NO
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLuo, L., et al. 2007. Nat. Chem. Biol. 3, 722.