324769 Endostatin, Mouse, Recombinant, Pichia pastoris

324769
  
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      Áttekintés

      Replacement Information
      Description
      OverviewRecombinant, mouse endostatin expressed in Pichia pastoris. Endostatin is a ~20 kDa C-terminal fragment of collagen XVIII that acts as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. It causes the arrest of endothelial cells in the G1 phase. Induces apoptosis in HUVE and MHVE cell lines by possibly reducing the levels of Bcl-2 and Bcl-xL proteins.
      Catalogue Number324769
      Brand Family Calbiochem®
      References
      ReferencesDixelius, J., et al. 2000. Blood 95, 3403. Boehm, T., et al. 1999. Yeast 15, 563. Dhanabal, M., et al. 1999. Biochem. Biophys. Res. Commun. 258, 345. Dhanabal, M., et al. 1999. J. Biol. Chem. 274, 11721. Moulton, K.S., et al. 1999. Circulation 99, 1726. OʹReilly, M.S., et al. 1997. Cell 88, 277.
      Product Information
      DeclarationSold under license of U.S. Patents 6,764,995, 6,746,865 and corresponding patents.
      FormLiquid
      FormulationIn 66 mM sodium phosphate, 59 mM NaCl, 17 mM citric acid, pH 6.2.
      Applications
      Biological Information
      Biological activity3 µg/ml endostatin will inhibit 50% tube formation.
      Purity≥95% by HPLC
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsEndotoxin: ≤0.5 EU/mg protein
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Endostatin, Mouse, Recombinant, Pichia pastoris Certificates of Analysis

      TitleLot Number
      324769

      References

      Hivatkozások áttekintése
      Dixelius, J., et al. 2000. Blood 95, 3403. Boehm, T., et al. 1999. Yeast 15, 563. Dhanabal, M., et al. 1999. Biochem. Biophys. Res. Commun. 258, 345. Dhanabal, M., et al. 1999. J. Biol. Chem. 274, 11721. Moulton, K.S., et al. 1999. Circulation 99, 1726. OʹReilly, M.S., et al. 1997. Cell 88, 277.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-October-2007 JSW
      DescriptionRecombinant, mouse endostatin expressed in Pichia pastoris. Endostatin is a ~20 kDa C-terminal fragment of collagen XVIII that acts as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. It causes the arrest of endothelial cells in the G1 phase. Induces apoptosis in HUVE and MHVE cell lines by possibly reducing the levels of Bcl-2 and Bcl-xL proteins.
      FormLiquid
      FormulationIn 66 mM sodium phosphate, 59 mM NaCl, 17 mM citric acid, pH 6.2.
      Concentration Label Please refer to vial label for lot-specific concentration
      Purity≥95% by HPLC
      ContaminantsEndotoxin: ≤0.5 EU/mg protein
      Biological activity3 µg/ml endostatin will inhibit 50% tube formation.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesDixelius, J., et al. 2000. Blood 95, 3403. Boehm, T., et al. 1999. Yeast 15, 563. Dhanabal, M., et al. 1999. Biochem. Biophys. Res. Commun. 258, 345. Dhanabal, M., et al. 1999. J. Biol. Chem. 274, 11721. Moulton, K.S., et al. 1999. Circulation 99, 1726. OʹReilly, M.S., et al. 1997. Cell 88, 277.