330655 Estrogen Receptorα, Human, Recombinant, S. frugiperda

330655
  
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      Áttekintés

      Replacement Information
      Description
      Overview

      This product has been discontinued.




      We apologize for the inconvenience, but we do not currently have an alternative product.






      Recombinant, human estrogen receptor-α expressed in S. frugiperda insect cells. A hormone-inducible transcription factor that can positively or negatively regulate expression of many genes involved in tissue growth and differentiation. ER-α is essential for induction of the oxytocin receptor by estrogen. Activated ER-α is involved in the modulation of transcription triggered by AP-1. Provided in a soluble, functionally-active form. Binds to estradiol (Kd = 300 pM) and to a fluorescein-labeled estrogen response element (ERE; Kd = 10 nM). Suitable for in vitro transcription assays.
      Catalogue Number330655
      Brand Family Calbiochem®
      SynonymsER-α
      References
      ReferencesTeyssier, C., et al. 2001. J. Biol. Chem. 276, 36361.
      Young, L.T., et al. 1998. NeuroReport 9, 933.
      Tzukeman, M.T., et al. 1994. Mol. Endocrinol. 8, 21.
      Beekman, J.M., et al. 1993. Mol. Endocrinol. 7, 1266.
      Obourn, J.D., et al. 1993. Biochemistry 32, 6229.
      Product Information
      ActivityBinds ≥ 960 pmol/[³H]-estradiol/ml
      FormLiquid
      FormulationIn 500 mM KCl, 50 mM Tris, 2 mM DTT, 1 mM EDTA, 1 mM sodium vanadate, 10% glycerol, 0.02% NaN₃, pH 7.5.
      Applications
      Biological Information
      Purity≥80% by SDS-PAGE
      Specific ActivityBinds ≥ 5,000 pmol [³H]-estradiol/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). DO NOT VORTEX.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Estrogen Receptorα, Human, Recombinant, S. frugiperda Certificates of Analysis

      TitleLot Number
      330655

      References

      Hivatkozások áttekintése
      Teyssier, C., et al. 2001. J. Biol. Chem. 276, 36361.
      Young, L.T., et al. 1998. NeuroReport 9, 933.
      Tzukeman, M.T., et al. 1994. Mol. Endocrinol. 8, 21.
      Beekman, J.M., et al. 1993. Mol. Endocrinol. 7, 1266.
      Obourn, J.D., et al. 1993. Biochemistry 32, 6229.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-March-2011 JSW
      SynonymsER-α
      DescriptionRecombinant, human estrogen receptor-α expressed in S. frugiperda insect cells. A hormone-inducible transcription factor that can positively or negatively regulate the expression of many genes involved in tissue growth and differentiation. Provided in a soluble, functionally active form. Binds to estradiol (Kd = 300 pM) and to fluorescein-labeled estrogen response element (ERE; Kd = 10 nM). Suitable for in vitro transcription assays.
      FormLiquid
      FormulationIn 500 mM KCl, 50 mM Tris, 2 mM DTT, 1 mM EDTA, 1 mM sodium vanadate, 10% glycerol, 0.02% NaN₃, pH 7.5.
      Purity≥80% by SDS-PAGE
      Specific activityBinds ≥ 5,000 pmol [³H]-estradiol/mg protein
      ActivityBinds ≥ 960 pmol/[³H]-estradiol/ml
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). DO NOT VORTEX.
      Toxicity Standard Handling
      ReferencesTeyssier, C., et al. 2001. J. Biol. Chem. 276, 36361.
      Young, L.T., et al. 1998. NeuroReport 9, 933.
      Tzukeman, M.T., et al. 1994. Mol. Endocrinol. 8, 21.
      Beekman, J.M., et al. 1993. Mol. Endocrinol. 7, 1266.
      Obourn, J.D., et al. 1993. Biochemistry 32, 6229.

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      Kategóriák

      Life Science Research > Proteins and Enzymes > Other Proteins