331500 Etazolate, Hydrochloride

331500
  
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      Áttekintés

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We apologize for the inconvenience, but we do not currently have an alternative product. For related products, please refer to our complete listing of phosphodiesterase inhibitors.





      A selective inhibitor of c-AMP-specific phosphodiesterase (PDE IV; IC50 = 2 µM). Also inhibits TNF-α production in cardiac tissue (IC50 = 2.1 µM).
      Catalogue Number331500
      Brand Family Calbiochem®
      Synonyms1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester, HCl, SQ20009
      References
      ReferencesBergman, M.R., and Holycross, B.J. 1996. J. Pharmacol. Exp. Therap. 279, 247. Tomes, C., et al. 1993. Cell Signal. 5, 615. Ahluwalia, G.S., and Rhoads, A.R. 1982. Biochem. Pharmacol. 31, 665.
      Product Information
      CAS number51022-77-6
      FormPale yellow solid
      Hill FormulaC₁₄H₁₉N₅O₂ · HCl
      Chemical formulaC₁₄H₁₉N₅O₂ · HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPDE 4
      Primary Target IC<sub>50</sub>2 µM
      Secondary targetTNF-α production in cardiac tissue (IC₅₀ = 2.1 µM)
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Etazolate, Hydrochloride Certificates of Analysis

      TitleLot Number
      331500

      References

      Hivatkozások áttekintése
      Bergman, M.R., and Holycross, B.J. 1996. J. Pharmacol. Exp. Therap. 279, 247. Tomes, C., et al. 1993. Cell Signal. 5, 615. Ahluwalia, G.S., and Rhoads, A.R. 1982. Biochem. Pharmacol. 31, 665.

      Brochure

      Title
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-June-2008 RFH
      Synonyms1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester, HCl, SQ20009
      DescriptionA selective cAMP-specific phosphodiesterase (PDE IV) inhibitor (IC50 = 2 µM). Also inhibits TNF-α production in cardiac tissue (IC50 = 2.07 µM).
      FormPale yellow solid
      CAS number51022-77-6
      Chemical formulaC₁₄H₁₉N₅O₂ · HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (25 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Toxicity Irritant
      ReferencesBergman, M.R., and Holycross, B.J. 1996. J. Pharmacol. Exp. Therap. 279, 247. Tomes, C., et al. 1993. Cell Signal. 5, 615. Ahluwalia, G.S., and Rhoads, A.R. 1982. Biochem. Pharmacol. 31, 665.