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Cleaning in Place Solutions
Tailor-Made, Ready-to-Use

Merck’s tailor-made, top quality Cleaning in Place solutions help you save time, money and effort. Instead of preparing your own solutions, simply order the volumes and concentrations you require from our new GMP process solutions plant – then integrate them into your own cleanroom straight away. Job done!
Increase the Bioburden Control and Re-Usability of Your Purification Steps
Every year, biopharmaceutical production facilities use vast quantities of Cleaning in Place (CIP) solutions to maintain the purity their processes demand. And every year, more and more companies order the tailor-made products they need from Merck, rather than preparing them themselves. Why? Because they know from experience that our top quality, ready-for-use products can save time and money – and reduce the risk for their employees too.
Click here to start using our CIP Calculator.
Protect Your Chromatography Media and Ultrafiltration / TFF Devices
Merck’s high-quality solutions for cleaning and storing of chromatography media such as our Fractogel® and ProSep® resins, as well as ultrafiltration Pellicon® cassettes, are designed to meet the specific demands of our customers in the biopharmaceutical industry. Our products fulfill the highest requirements to purity and reliability, and they effectively prevent contamination of your valuable purification equipment. All our solutions are manufactured under GMP conditions and feature low bioburden levels. Moreover, our cleaning solutions bear the EMPROVE® bio trademark for exceptional quality and documentation support.
GMP Grade CIP/SIP Solutions
To ensure the highest standards of purity and quality, all our CIP solutions are produced in a cleanroom at our new GMP process solutions plant in Darmstadt, Germany. We use only pharmaceutical-quality raw materials (such as sodium hydroxide), and highly purified water according to European and US pharmacopoeia (Ph. Eur., USP). As a result, you can integrate our solutions directly into your own cleanroom without further ado.

CIP High-Level Product Offerings
Sodium hydroxide solutions: 0.05 N – 50%
Sodium hydroxide solutions, low iron: 20/25/30%
Hydrochloric acid and acetic acid in different concentrations
Ethanol 20% and PAB solutions for sanitization of chromatography resins
Sodium hydroxide pellets Ph Eur, USP
Sodium hydroxide pellets Ph Eur, USP
GMP Solutions Plant in Darmstadt
GMP solutions plant in DarmstadtOur GMP solutions plant in Darmstadt sets standards for quantity and quality. The dispersion unit can dissolve up to 10 tons of solid raw materials per day; IBCs are filled in a clean room to ensure the highest standards of purity.
Forward-Looking Products and Support
In addition to tailor-made solutions, Merck also provides technical support and full regulatory documentation to simplify approval and validation procedures. Since all our Cleaning in Place products comply with GMP guidelines, you’re well prepared for the future in this increasingly regulated segment.
New: CIP Solutions in Single-Use Bags

We now offer these solutions in single-use bag packaging.

Webinar: Industry Best Practices for TFF Cassette Reuse and Storage - Watch Now

Industry Best Practices for TFF Cassette Reuse and Storage

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