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126850 α₁-PDX, Human, Recombinant, E. coli - Calbiochem

Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag® sequence and a FLAG®-tag.

α₁-PDX, Human, Recombinant, E. coli - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α₁-Antitrypsin Portland

Primary Target: Furin-dependent processing of protein precursors
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126850
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Overview

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Pricing & Availability

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126850-2.5MG
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      Description
      OverviewRecombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag® sequence and a FLAG®-tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). Extracellular application of α1-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors. Useful for in vivo and in vitro furin inhibition assays.
      Catalogue Number126850
      Brand Family Calbiochem®
      Synonymsα₁-Antitrypsin Portland
      References
      ReferencesBassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
      Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2864.
      Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 7293.
      Product Information
      ATP CompetitiveN
      FormLyophilized solid
      FormulationLyophilized from PBS.
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFurin-dependent processing of protein precursors
      Primary Target K<sub>i</sub>600 pM against furin-dependent processing of protein precursors
      Purity≥80% by SDS-PAGE
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Yes
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      α₁-PDX, Human, Recombinant, E. coli - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      α₁-PDX, Human, Recombinant, E. coli - Calbiochem Certificates of Analysis

      TitleLot Number
      126850

      References

      Reference overview
      Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
      Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2864.
      Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 7293.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2008 JSW
      Synonymsα₁-Antitrypsin Portland
      DescriptionRecombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His·Tag® and a FLAG·Tag™. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). α1-PDX can be used in extracellular applications to block the processing of furin substrates. α1-PDX has been shown to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.
      FormLyophilized solid
      FormulationLyophilized from PBS.
      Concentration Label Please refer to vial label for lot-specific concentration
      Purity≥80% by SDS-PAGE
      SolubilityH₂O (2.5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Yes
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
      Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2864.
      Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 7293.