104551 ACC2 Inhibitor, CD-017-0191 - Calbiochem

104551
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₁₉N₃O₃S

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104551-10MG
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      Description
      OverviewA cell-permeable and selective inhibitor of human Acetyl-CoA carboxylase 2 (ACC2) (IC50 = 2.8 µM), which does not inhibit human ACC1 at all at concentrations up to 100 µM, in vitro. It is also shown to inhibit the growth of yeast (IC50 = 3.8 µM), in which the native ACC1 gene is replaced with the human ACC2 strain; but not with the human ACC1 strain at concentrations ≤ 100 µM. This compound is not demonstrated to be toxic to human cells in culture at concentrations up to 10 µM.
      Catalogue Number104551
      Brand Family Calbiochem®
      Synonyms2-((2-(4-isopropoxyphenyl)-5-methyloxazol-4-yl)methylthio)oxazolo[4,5-b]pyridine
      References
      ReferencesMarjanovic, J., et al. 2010 Proc. Natl. Acad. Sci. 107, 9093.
      Product Information
      FormOff-white solid
      Hill FormulaC₂₀H₁₉N₃O₃S
      Chemical formulaC₂₀H₁₉N₃O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ACC2 Inhibitor, CD-017-0191 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      ACC2 Inhibitor, CD-017-0191 - Calbiochem Certificates of Analysis

      TitleLot Number
      104551

      References

      Reference overview
      Marjanovic, J., et al. 2010 Proc. Natl. Acad. Sci. 107, 9093.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-February-2011 RFH
      Synonyms2-((2-(4-isopropoxyphenyl)-5-methyloxazol-4-yl)methylthio)oxazolo[4,5-b]pyridine
      DescriptionA cell-permeable and selective inhibitor of human Acetyl-CoA carboxylase 2 (ACC2) (IC50 = 2.8 µM), which does not inhibit human ACC1 at all at concentrations up to 100 µM, in vitro. It is also shown to inhibit the growth of yeast (IC50 = 3.8 µM), in which the native ACC1 gene is replaced with the human ACC2 strain; but not with the human ACC1 strain at concentrations ≤ 100 µM. This compound is not demonstrated to be toxic to human cells in culture at concentrations up to 10 µM.
      FormOff-white solid
      Chemical formulaC₂₀H₁₉N₃O₃S
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMarjanovic, J., et al. 2010 Proc. Natl. Acad. Sci. 107, 9093.