123850 AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem

123850
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₃H₉BrO₃ 4906-68-7

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123850-25MG
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      Description
      OverviewA cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50 = 460 nM in AKR1C1 overexpressing BAECs).
      Catalogue Number123850
      Brand Family Calbiochem®
      SynonymsAldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
      References
      ReferencesEl-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
      El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.
      Product Information
      CAS number4906-68-7
      FormWhite solid
      Hill FormulaC₁₃H₉BrO₃
      Chemical formulaC₁₃H₉BrO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥94% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      123850

      References

      Reference overview
      El-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
      El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-July2-2012 JSW
      SynonymsAldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
      DescriptionA cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50 = 460 nM in AKR1C1 overexpressing BAECs).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number4906-68-7
      Chemical formulaC₁₃H₉BrO₃
      Structure formulaStructure formula
      Purity≥94% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesEl-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
      El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.