123855 AKR1C3 Inhibitor - Calbiochem

123855
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄H₁₀F₃NO₂

Pricing & Availability

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123855-25MG
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      Botol kaca 25 mg
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      Description
      OverviewA cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
      Catalogue Number123855
      Brand Family Calbiochem®
      Synonyms3-(4-(Trifluoromethyl)phenylamino)benzoic acid
      References
      ReferencesAdeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
      Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.
      Product Information
      FormWhite powder
      Hill FormulaC₁₄H₁₀F₃NO₂
      Chemical formulaC₁₄H₁₀F₃NO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AKR1C3 Inhibitor - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      AKR1C3 Inhibitor - Calbiochem Certificates of Analysis

      TitleLot Number
      123855

      References

      Reference overview
      Adeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
      Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-July-2012 JSW
      Synonyms3-(4-(Trifluoromethyl)phenylamino)benzoic acid
      DescriptionA cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₁₀F₃NO₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAdeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
      Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.