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14-614M ALK4 Protein, active, 250 µg

Active, N-terminal GST-tagged, recombinant, human ALK4 amino acids 150-end. For use in Kinase Assays.

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14-614M
250 µg  Also available in 10 μg size (cat#14-614) and in bulk (cat#14-614-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-614M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionALK4 Protein, active, 250 µg
      OverviewN-terminal GST-tagged, recombinant, human ALK4 amino acids 150-end.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal GST-tagged, recombinant, human ALK4 amino acids 150-end. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman ALK4 expressed by baculovirus in Sf21 insect cells.
      Entrez Gene Number
      Entrez Gene SummaryActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
      Gene Symbol
      • ACVR1B
      • ALK-4
      • ACVRLK4
      • ALK4
      • SKR2
      • ActRIB
      • ACTR-IB
      • ACTRIB
      Protein TargetALK4
      Purification MethodGlutathione-agarose
      Target Sub-FamilyTKL
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P36896 # On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
      COFACTOR: Magnesium or manganese (By similarity).
      SIZE: 505 amino acids; 56807 Da
      SUBUNIT: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
      SIMILARITY: SwissProt: P36896 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. & Contains 1 GS domain. & Contains 1 protein kinase domain.
      Molecular Weight63.8kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of casein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-614) and in bulk (cat#14-614-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-614M 04053252924316

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-614 ALK4 Protein, active, 10 µg Show Pricing & Availability

      Product Families

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      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases