118500 Sigma-AldrichATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem
ATM Kinase Inhibitor, CAS 587871-26-9, is a cell-permeable, potent, ATP-competitive inhibitor of ATM Kinase (IC₅₀ = 13 nM; Ki = 2.2 nM).
More>> ATM Kinase Inhibitor, CAS 587871-26-9, is a cell-permeable, potent, ATP-competitive inhibitor of ATM Kinase (IC₅₀ = 13 nM; Ki = 2.2 nM). Less<<Synonyms: 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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587871-26-9 | C₂₁H₁₇NO₃S₂ |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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118500-10MG |
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Botol kaca | 10 mg |
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118500-2MG |
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Botol kaca | 2 mg |
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Description | |
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Overview | A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available. |
Catalogue Number | 118500 |
Brand Family | Calbiochem® |
Synonyms | 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933 |
References | |
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References | Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056. Lau, A., et al. 2005. Nat. Cell Biol. 7, 493. Hickson, I., et al. 2004. Cancer Res. 64, 9152. |
Product Information | |
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CAS number | 587871-26-9 |
ATP Competitive | Y |
Form | White solid |
Hill Formula | C₂₁H₁₇NO₃S₂ |
Chemical formula | C₂₁H₁₇NO₃S₂ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | ATM Kinase |
Primary Target IC<sub>50</sub> | 13 nM |
Primary Target K<sub>i</sub> | 2.2 nM for ATM kinase |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Safety Information according to GHS |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
118500-10MG | 04055977224030 |
118500-2MG | 07790788047894 |
Documentation
ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem MSDS
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ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem Certificates of Analysis
Title | Lot Number |
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118500 |
References
Reference overview |
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Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056. Lau, A., et al. 2005. Nat. Cell Biol. 7, 493. Hickson, I., et al. 2004. Cancer Res. 64, 9152. |