124037 Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem

124037
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₁₀H₈ClNO 28755-03-5

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124037-25MG
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      Description
      OverviewA cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50 = 30 mg/kg; 5 times/wk for 3 wks via p.o.) in vivo.
      Catalogue Number124037
      Brand Family Calbiochem®
      Synonyms3-Chloroacetyl-indole, 2-Chloro-1-(1H-indol-3-yl)ethanone
      References
      ReferencesKim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.
      Product Information
      CAS number28755-03-5
      FormPink solid
      Hill FormulaC₁₀H₈ClNO
      Chemical formulaC₁₀H₈ClNO
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      124037

      References

      Reference overview
      Kim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-July-2012 JSW
      Synonyms3-Chloroacetyl-indole, 2-Chloro-1-(1H-indol-3-yl)ethanone
      DescriptionA cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases, including PI-3 Kinase (60% inhibition at 10 µM). Effectively inhibits Akt-mediated cellular GSK3β Ser9 and mTOR Ser2448 phosphorylation (4 µM in HCT116 cultures) in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth by 50% when administered at an oral dosage of 30 mg/kg in mice (5 times/wk for 3 wks) in vivo.
      FormPink solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number28755-03-5
      Chemical formulaC₁₀H₈ClNO
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.