176901 Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem

176901
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₈₁H₁₅₀N₄₂O₁₇

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176901-1MG
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      Description
      OverviewA cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells.
      Catalogue Number176901
      Brand Family Calbiochem®
      SynonymsAnthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
      References
      ReferencesPeinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
      Tonello, F., et. al. 2002. Nature 418, 386.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₈₁H₁₅₀N₄₂O₁₇
      Chemical formulaC₈₁H₁₅₀N₄₂O₁₇
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetanthrax LF metalloprotease
      Primary Target K<sub>i</sub>1 nM against Anthrax lethal factor (LF) metalloprotease
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem Certificates of Analysis

      TitleLot Number
      176901

      References

      Reference overview
      Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
      Tonello, F., et. al. 2002. Nature 418, 386.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-April-2008 RFH
      SynonymsAnthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
      DescriptionA cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (Ki = 49 nM.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₈₁H₁₅₀N₄₂O₁₇
      Peptide SequenceAc-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml), 5% Acetic Acid (5 mg/ml), or H₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPeinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
      Tonello, F., et. al. 2002. Nature 418, 386.