171610 Anti-Amyloid Precursor Protein, C-Terminal (751-770) Rabbit pAb

171610
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Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
H Rb Polyclonal Antibody

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171610-50UL
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      Description
      OverviewRecognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa).
    • Antibody Target Gene Symbol: APP
    • Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2
    • Entrez Gene Name: amyloid beta (A4) precursor protein
    • Hu Entrez ID: 351 (Related Antibodies: PC729, PC152,PC151, PC150, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537)
    • Mu Entrez ID: 11820
    • Rat Entrez ID: 54226
    • Catalogue Number171610
      Brand Family Calbiochem®
      SynonymsAnti-0443, Anti-APP-CT20
      References
      ReferencesPinnix, I., et al. 2001. J. Biol. Chem. 276, 481.
      Product Information
      DeclarationPurchase of this material is for research use only. Users are invited to request a license from Mayo prior to using the 0433 antibody or any derivatives for clinical diagnostic or therapeutic purposes. For license information, please contact: Mayo Medical Ventures, Office of Technology Commercialization (507) 284-8878, 200 First Street SW, Rochester, MN 55905-001.
      FormLiquid
      Quality LevelMQ100
      Applications
      Key Applications Immunoprecipitation
      Immunoblotting (Western Blotting)
      Immunofluorescence
      Immunohistochemistry
      Application NotesImmunoblotting (1:5000-1:20,000)
      Immunofluorescence (1:1000)
      Immunohistochemistry (1:1000)
      Immunoprecipitation (1:1000)
      Application CommentsVariables associated with assay conditions will dictate the proper working dilution.
      Biological Information
      Immunogena synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Amyloid Precursor Protein, C-Terminal (751-770) Rabbit pAb MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Amyloid Precursor Protein, C-Terminal (751-770) Rabbit pAb Certificates of Analysis

      TitleLot Number
      171610

      References

      Reference overview
      Pinnix, I., et al. 2001. J. Biol. Chem. 276, 481.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide

      Citations

      Title
    • Jonathan D. J. Wrigley, et al. (2005) Functional overexpression of γ-secretase reveals protease independent trafficking functions and a critical role of lipids for protease activity. Journal of Biological Chemistry 280, 12523-12535.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-July-2007 RFH
      SynonymsAnti-0443, Anti-APP-CT20
      ApplicationImmunoblotting (1:5000-1:20,000)
      Immunofluorescence (1:1000)
      Immunohistochemistry (1:1000)
      Immunoprecipitation (1:1000)
      DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa).
      BackgroundAmyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP is cleaved by alpha-secretase to generate sAPPα and CTFα, which is the C-terminal membrane, associated product of α-secretase cleavage. α-secretase cleaves in the Aβ domain. β-secretase cleavage of APP at the N-terminal end of the Aβ sequence results in sAPPβ and CTFβ. Both CTFα and CTFβ are cleaved at the C-terminal end of the Aβ transmembrane domain to generate CTFγ. The antibody (171610) detects CTFγ fragment, which migrates at about 6 kDa on SDS-PAGE gels.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH
      IsotypeIgG
      Specieshuman
      FormLiquid
      CommentsVariables associated with assay conditions will dictate the proper working dilution.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesPinnix, I., et al. 2001. J. Biol. Chem. 276, 481.
      Citation
    • Jonathan D. J. Wrigley, et al. (2005) Functional overexpression of γ-secretase reveals protease independent trafficking functions and a critical role of lipids for protease activity. Journal of Biological Chemistry 280, 12523-12535.