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ABN898 Anti-BMP2

Anti-BMP2, Cat. No. ABN898, is a highly specific rabbit polyclonal antibody that targets bone morphogenetic protein 2 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-BMP2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: BMP2, BMP2A UniProt Number: P12643
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ABN898
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN898
      ReplacesABN303
      DescriptionAnti-BMP2
      Alternate Names
      • Bone morphogenetic protein 2
      • BMP-2
      • BMP-2A
      • Bone morphogenetic protein 2A
      Background InformationBone morphogenetic protein 2 (UniProt: P12643; also known as BMP-2, BMP-2A, Bone morphogenetic protein 2A) is encoded by the BMP2 (also known as BMP2A) gene (Gene ID 650) in human. BMP2 is a member of the transforming growth factor-beta (TGF-beta) superfamily. It is synthesized as a 60-kDa precursor that is processed in the secretory pathway to a small 18-kDa monomer; 2 monomers then associate to form the active homodimer, which binds to its receptor. BMP2 can induce bone formation and regeneration during early embryonic development. It is also involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP2 is known to induce cartilage and bone formation and stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A, which leads to increased expression of ATF4 that plays a critical role in osteoblast differentiation.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-BMP2, Cat. No. ABN898, is a highly specific rabbit polyclonal antibody that targets bone morphogenetic protein 2 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BMP2 immunoreactivity in human prostate cancer, cerebellum, and tonsil tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant protein composed of the propeptide C-terminal region and the mature human BMP2 N-terminal region.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody targets a region present in Prepro-, pro-, and mature human BMP2.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BMP2
      • BMP2A
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~45 kDa observed. 44.70/42.48/12.90 kDa (Prepro-/pro-/mature human BMP2 monomer). Target band size appears larger due to glycosylation and dimerization. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human kidney tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected BMP2 in 10 µg of human kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN898 04054839092084