Millipore Sigma Vibrant Logo

MAB5432 Anti-CREB Antibody

View Products on
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited Availability
Limited Availability
In Stock 
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers


      Contact Customer Service


      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RELISA, WBMPurifiedMonoclonal Antibody
      Catalogue NumberMAB5432
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CREB Antibody
      Alternate Names
      • cAMP-response Element Binding Protein
      Background InformationCREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. CREB promotes outgrowth and differentiation as a mediator of Neurotrophin pathways. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling.
      Product Information
      HS Code3002 15 90
      • Jurkat nuclear extract, A-431 whole cell lysate
      PresentationPurified immunoglobulin. Liquid in PBS containing 0.1% sodium azide.
      Quality LevelMQ100
      ApplicationAnti-CREB Antibody is a Mouse Monoclonal Antibody for detection of CREB also known as cAMP-response Element Binding Protein & has been validated in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-5 μg/mL. Recognizes the ~43kDa protein.

      ELISA: 0.1-1.0 μg/mL

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant CREB-A protein.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityReacts with CREB.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
      Gene Symbol
      • CREB1
      • MGC9284
      • CREB
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16220 # This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE.
      SIZE: 341 amino acids; 36688 Da
      SUBUNIT: Binds DNA as a dimer. Interacts PPRC1 and with HTLV-1 Tax-1.
      PTM: Stimulated by phosphorylation. Phosphorylation of both Ser- 133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP and EP300 binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: P16220 ## Belongs to the bZIP family. & Contains 1 bZIP domain. & Contains 1 KID (kinase-inducible) domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Global Trade Item Number
      Catalogue Number GTIN
      MAB5432 04053252314841


      Anti-CREB Antibody MSDS


      Safety Data Sheet (SDS) 

      Anti-CREB Antibody Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-CREB - 3214387 3214387
      MOUSE ANTI-CREB - 3286061 3286061
      MOUSE ANTI-CREB - 3869195 3869195
      MOUSE ANTI-CREB - 4082578 4082578
      MOUSE ANTI-CREB -2567009 2567009


      Reference overviewPub Med ID
      Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
      Orr, AG; Hsiao, EC; Wang, MM; Ho, K; Kim, DH; Wang, X; Guo, W; Kang, J; Yu, GQ; Adame, A; Devidze, N; Dubal, DB; Masliah, E; Conklin, BR; Mucke, L
      Nature neuroscience  18  423-34  2015

      Show Abstract
      25622143 25622143
      Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling.
      Lin-Moshier, Y; Sebastian, PJ; Higgins, L; Sampson, ND; Hewitt, JE; Marchant, JS
      The Journal of biological chemistry  288  355-67  2013

      Show Abstract
      23148228 23148228
      Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease.
      Yiu, AP; Rashid, AJ; Josselyn, SA
      Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  36  2169-86  2011

      Show Abstract
      21734652 21734652
      Identification of drug candidates which increase cytochrome c oxidase activity in deficient patient fibroblasts.
      Maj M, Sriskandarajah N, Hung V, Browne I, Shah B, Weadge A, Jamieson NL, Tropak M, Cameron JM, Addis JB, Robinson BH
      Mitochondrion  2010

      Show Abstract
      21050896 21050896
      Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin.
      Yu Fukuda,Thomas L Berry,Matthew Nelson,Christopher L Hunter,Koki Fukuhara,Hideki Imai,Shinji Ito,Ann-Charlotte Granholm-Bentley,Allen P Kaplan,Tatsuro Mutoh
      Molecular and cellular neurosciences  45  2010

      Show Abstract
      20600926 20600926

      Related Products & Applications

      Related Products

      Product Families


      Life Science Research > Antibodies and Assays > Primary Antibodies