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MABT913-25UG Anti-Cytokeratin 19 Antibody, clone TROMA-3

Anti-Cytokeratin 19, clone TROMA-3 Antibody, Cat. No. MABT913-25UG, validated for use in Western Blotting and Electron Microscopy, Immunohistochemistry (Paraffin), Immunoprecipitation and Immunofluorescence.

Anti-Cytokeratin 19 Antibody, clone TROMA-3 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Gene Symbol: Krt19, Krt1-19 UniProt Number: P19001
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MABT913-25UG
25 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, EM, IH(P), IP, IFRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT913-25UG
      DescriptionAnti-Cytokeratin 19 Antibody, clone TROMA-3
      Alternate Names
      • Keratin
      • type I cytoskeletal 19
      • CK-19
      • Keratin-19
      • K19
      Background InformationKeratin, type I cytoskeletal 19 (UniProt: P19001; also known as Cytokeratin-19, CK-19, Keratin-19, K19) is encoded by the Krt19 (also known as Krt1-19) gene (Gene ID: 16669) in murine species. CK-19 belongs to the family of intermediate filament (IF) family, but differs from other IF proteins in lacking the C-terminal tail domain. About 20 different cytokeratin proteins have been reported in higher animals in varying combinations during various stages of development. CK-19 is normally expressed in the lining of the gastroenteropancreatic and hepatobiliary tracts. It is expressed throughout embryonic development with highest levels observed at 8.5 days post coitum. Its expression is shown to decrease by day 11.5 and then is increased again by 17.5 days post coitum. CK-19 is shown to be involved in the organization of myofibrils and together with keratin 8, it helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. CK-19 has been shown to be an independent prognostic factor for pancreatic neuroendocrine tumors, especially the insulin-negative tumors. TROMA 3 has been found to stain trophoblastoma TDM.1 cells, a subpopulation of the retinoic acid.-induced F9 and PCC3/ND1 cells, and in 5-azacytidine-treated 1246 cells.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Cytokeratin 19, clone TROMA-3 Antibody, Cat. No. MABT913-25UG, validated for use in Western Blotting and Electron Microscopy, Immunohistochemistry (Paraffin), Immunoprecipitation and Immunofluorescence.
      Key Applications
      • Western Blotting
      • Electron Microscopy
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Cytokeratin 19 in mouse lung tissue.
      Biological Information
      ImmunogenPurified intermediate filaments from DM1 (Trophoblatoma) cell line.
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      SpecificityClone TROMA-3 detects cytokeratin 19 in human and murine cells.
      IsotypeIgG2a
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteMouse, Human.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Krt19
      • Krt1-19
      Purification MethodProtein G purified
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT913-25UG 04054839420917