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ABE558 Anti-Ku70 Protein Antibody

Detect Ku70 Protein using this rabbit polyclonal antibody, Anti-Ku70 Protein Antibody validated for use in western blotting, IP & IHC (Paraffin).

Anti-Ku70 Protein Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: XRCC6, G22P1 UniProt Number: P12956
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ABE558
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IP, IH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE558
      ReplacesAB1358
      DescriptionAnti-Ku70 Protein Antibody
      Alternate Names
      • X-ray repair cross-complementing protein 6
      • 5'-deoxyribose-5-phosphate lyase Ku70
      • 5'-dRP lyase Ku70
      • 70 kDa subunit of Ku antigen
      • ATP-dependent DNA helicase 2 subunit 1
      • ATP-dependent DNA helicase II 70 kDa subunit
      • CTC box-binding factor 75 kDa subunit
      • CTC75
      • CTCBF
      • DNA repair protein XRCC6
      • Lupus Ku autoantigen protein p70
      • Ku70
      • Thyroid-lupus autoantigen
      • TLAA
      • X-ray repair complementing defective repair in Chinese hamster cells 6
      Background InformationLupus Ku autoantigen protein p70 (Ku70) is also known as X-ray repair cross-complementing protein 6 (XRCC6), 5'-dRP lyase Ku70, CTC box-binding factor 75 kDa subunit (CTC75, CTCBF) or Thyroid-lupus autoantigen (TLAA). Ku70 is a single stranded DNA-dependent ATP-dependent helicase that plays a role in chromosome translocation and DNA non-homologous end joining (NHEJ) required for double-strand break repair and recombination. The XRCC5/6 (Ku80/Ku70) dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK, and that dimer, together with APEX1, acts as a negative regulator of transcription. Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to XRCC5 (Ku80) and XRCC6 (Ku70).
      References
      Product Information
      FormatPurified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Ku70 Protein using this rabbit polyclonal antibody, Anti-Ku70 Protein Antibody validated for use in western blotting, IP & IHC (Paraffin).
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunohistochemistry (Paraffin)
      Application NotesImmunoprecipitation Analysis: A representative lot immunoprecipitated Ku70 Protein in 0.5 mg of HeLa cell lysate.
      Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Ku70 Protein in human prostate carcinoma cells and human testis tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Ku70 Protein near N-Terminus.
      EpitopeNear N-Terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Ku70 Protein near N-Terminus.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • XRCC6
      • G22P1
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight~70 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Ku70 Protein in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE558 04053252906404