196419 BAPTA/AM - CAS 126150-97-8 - Calbiochem

196419
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₃₄H₄₀N₂O₁₈ 126150-97-8

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
196419-100MG
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      Ampul plastik 100 mg
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      196419-25MG
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          Description
          OverviewMembrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Abolishes vitamin D3-induced increase in intracellular Ca2+. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
          Catalogue Number196419
          Brand Family Calbiochem®
          Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester
          References
          ReferencesBissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
          Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
          Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
          Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
          Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
          Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
          Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
          Tsien, R.Y. 1981. Nature 290, 527.
          Tsien, R.Y. 1980. Biochemistry 19, 2396.
          Product Information
          CAS number126150-97-8
          FormLight yellow solid
          Hill FormulaC₃₄H₄₀N₂O₁₈
          Chemical formulaC₃₄H₄₀N₂O₁₈
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥90% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          BAPTA/AM - CAS 126150-97-8 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          BAPTA/AM - CAS 126150-97-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          196419

          References

          Reference overview
          Bissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
          Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
          Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
          Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
          Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
          Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
          Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
          Tsien, R.Y. 1981. Nature 290, 527.
          Tsien, R.Y. 1980. Biochemistry 19, 2396.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure

          Citations

          Title
        • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
        • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2008 RFH
          Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester
          DescriptionMembrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number126150-97-8
          Chemical formulaC₃₄H₄₀N₂O₁₈
          Structure formulaStructure formula
          Purity≥90% by TLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Irritant
          ReferencesBissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
          Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
          Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
          Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
          Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
          Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
          Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
          Tsien, R.Y. 1981. Nature 290, 527.
          Tsien, R.Y. 1980. Biochemistry 19, 2396.
          Citation
        • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
        • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
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