196440 Batimastat - CAS 130370-60-4 - Calbiochem

196440
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Key Spec Table

Empirical FormulaCAS #
C₂₃H₃₁N₃O₄S₂ 130370-60-4

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196440-5MG
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      Description
      OverviewA Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 508408).
      Catalogue Number196440
      Brand Family Calbiochem®
      Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94
      References
      ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
      Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
      Parvathy, S., et al. 1998. Biochemistry 37, 1680.
      Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
      Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
      Moss, M.L., et al. 1997. Nature 385, 733.
      Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
      Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
      Wang, X., et al. 1994. Cancer Res. 54, 4726.
      Davies, B., et al. 1993. Cancer Res. 53, 2087.
      Product Information
      CAS number130370-60-4
      FormOff-white solid
      Hill FormulaC₂₃H₃₁N₃O₄S₂
      Chemical formulaC₂₃H₃₁N₃O₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationBatimastat, CAS 130370-60-4, is a potent inhibitor of a several metalloproteinases, including MMP-1, 2, 3, 7, 9, ΔMT1, ADAM8 & ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3 & 19 nM, respectively).
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Batimastat - CAS 130370-60-4 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Batimastat - CAS 130370-60-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      196440

      References

      Reference overview
      Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
      Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
      Parvathy, S., et al. 1998. Biochemistry 37, 1680.
      Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
      Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
      Moss, M.L., et al. 1997. Nature 385, 733.
      Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
      Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
      Wang, X., et al. 1994. Cancer Res. 54, 4726.
      Davies, B., et al. 1993. Cancer Res. 53, 2087.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-August-2010 RFH
      Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94
      DescriptionA Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number130370-60-4
      Chemical formulaC₂₃H₃₁N₃O₄S₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
      Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
      Parvathy, S., et al. 1998. Biochemistry 37, 1680.
      Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
      Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
      Moss, M.L., et al. 1997. Nature 385, 733.
      Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
      Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
      Wang, X., et al. 1994. Cancer Res. 54, 4726.
      Davies, B., et al. 1993. Cancer Res. 53, 2087.