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200980 Bikinin - CAS 188011-69-0 - Calbiochem

A cell-permeable nonsteroidal pyridinylamido compound that acts as an ATP-competitive inhibitor.

Bikinin - CAS 188011-69-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid, Arabidopsis GSK-3 Inhibitor, Arabidopsis SHAGGY-related Kinase Inhibitor, GSK-3-like Kinase BIN2 Inhibitor

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      188011-69-0C₉H₉BrN₂O₃
      Description
      OverviewA cell-permeable nonsteroidal pyridinylamido compound that acts as an ATP-competitive inhibitor against 7 of the 10 Arabidopsis thaliana GSK3's, BIN2 & ASKα/ γ/ε/ζ/ι/θ, but not ASKβ/δ or three other Arabidopsis Ser/Thr kinases, AtMPK4, AtMPK6, and AtAURORA1. The inhibitory activity is plant species-selective, as Bikinin exhibits much reduced activity against human Gsk-3β, Aurora B, Aurora C (45.6%, 69.4%, and 42.8% inhibition, respectively, with 10 µM Bikinin), and little or no activity against 74 other human kinases, nor does it affect GSK-3β-mediated dorsoventral axis formation during Xenopus embryo development. Bikinin at 30 µM is shown to bypass brassinolide (BL) and BRI1 and effectively activate brassinosteroid (BR) signaling responses in Arabidopsis thaliana seedings, including decreased BES1 phosphorylation, increased hypocotyl length, long and bending petioles, blade-shaped, pale-green leaves, as well as reduced lateral root density.
      Catalogue Number200980
      Brand Family Calbiochem®
      Synonyms4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid, Arabidopsis GSK-3 Inhibitor, Arabidopsis SHAGGY-related Kinase Inhibitor, GSK-3-like Kinase BIN2 Inhibitor
      References
      ReferencesRybel, B.D., et al. 2009. Chem. Biol. 16, 594.
      Product Information
      CAS number188011-69-0
      FormWhite solid
      Hill FormulaC₉H₉BrN₂O₃
      Chemical formulaC₉H₉BrN₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      200980 0

      Documentation

      Bikinin - CAS 188011-69-0 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Bikinin - CAS 188011-69-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      200980

      References

      Reference overview
      Rybel, B.D., et al. 2009. Chem. Biol. 16, 594.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid, Arabidopsis GSK-3 Inhibitor, Arabidopsis SHAGGY-related Kinase Inhibitor, GSK-3-like Kinase BIN2 Inhibitor
      DescriptionA cell-permeable nonsteroidal pyridinylamido compound that acts as an ATP-competitive inhibitor against 7 of the 10 Arabidopsis thaliana GSK3's, BIN2 & ASKα/ γ/ε/ζ/ι/θ, but not ASKβ/δ or three other Arabidopsis Ser/Thr kinases, AtMPK4, AtMPK6, and AtAURORA1. The inhibitory activity is plant species-selective, as Bikinin exhibits much reduced activity against human Gsk-3β, Aurora B, Aurora C (45.6%, 69.4%, and 42.8% inhibition, respectively, with 10 µM Bikinin), and little or no activity against 74 other human kinases, nor does it affect GSK-3β-mediated dorsoventral axis formation during Xenopus embryo development. Bikinin at 30 µM is shown to bypass brassinolide (BL) and BRI1 and effectively activate brassinosteroid (BR) signaling responses in Arabidopsis thaliana seedings, including decreased BES1 phosphorylation, increased hypocotyl length, long and bending petioles, blade-shaped, pale-green leaves, as well as reduced lateral root density.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number188011-69-0
      Chemical formulaC₉H₉BrN₂O₃
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRybel, B.D., et al. 2009. Chem. Biol. 16, 594.