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346007 Glucagon-Like Peptide 1 Receptor Agonist II - CAS 1371569-69-5 - Calbiochem

Glucagon-Like Peptide 1 Receptor Agonist II - CAS 1371569-69-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine , Glucagon-Like Peptide 1 Receptor Agonist II, Compound B

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346007
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1371569-69-5C₂₀H₁₇F₃N₂O₂S

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      Description
      OverviewA pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC50 = 0.66 µM and 99% efficacy (similar data with rat GLP-1 receptor), does not compete with radiolabelled GLP-1 in receptor binding assays, and is not active in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. In rodent islets, insulin secretion increases in a dose-dependent and glucose-dependent manner, either alone or in an additive fashion when combined with the endogenous GLP-1 peptide. In vivo, this molecule exhibits insulinotropic effects when dosed at 10mg/kg in SD rats undergoing an IVGTT and a hyperglycemic clamp. It is also shown to increase insulin secretion in perifusion assays involving normal and diabetic human islets ex vivo, at concentrations between 1 and 10 µM.
      Catalogue Number346007
      Brand Family Calbiochem®
      Synonyms4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine , Glucagon-Like Peptide 1 Receptor Agonist II, Compound B
      References
      ReferencesSloop, KW., et al. 2010. Diabetes. 59, 3099.
      Product Information
      CAS number1371569-69-5
      FormOff-white solid
      Hill FormulaC₂₀H₁₇F₃N₂O₂S
      Chemical formulaC₂₀H₁₇F₃N₂O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      346007-10MG 04055977214611

      Documentation

      Glucagon-Like Peptide 1 Receptor Agonist II - CAS 1371569-69-5 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Glucagon-Like Peptide 1 Receptor Agonist II - CAS 1371569-69-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      346007

      References

      Reference overview
      Sloop, KW., et al. 2010. Diabetes. 59, 3099.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-February-2011 RFH
      Synonyms4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine , Glucagon-Like Peptide 1 Receptor Agonist II, Compound B
      DescriptionA pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC50 = 0.66 µM and 99% efficacy (similar data with rat GLP-1 receptor), does not compete with radiolabelled GLP-1 in receptor binding assays, and is not active in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. In rodent islets, insulin secretion increases in a dose-dependent and glucose-dependent manner, either alone or in an additive fashion when combined with the endogenous GLP-1 peptide. In vivo, this molecule exhibits insulinotropic effects when dosed at 10mg/kg in SD rats undergoing an IVGTT and a hyperglycemic clamp. It is also shown to increase insulin secretion in perifusion assays involving normal and diabetic human islets ex vivo, at concentrations between 1 and 10 µM.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1371569-69-5
      Chemical formulaC₂₀H₁₇F₃N₂O₂S
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSloop, KW., et al. 2010. Diabetes. 59, 3099.