191501 InSolution™ 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem

191501
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₀BrN₃O 676596-65-9

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191501-500UG
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      Botol kaca 500 μg
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      Description
      OverviewA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.
      Catalogue Number191501
      Brand Family Calbiochem®
      References
      ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
      Product Information
      CAS number676596-65-9
      FormLiquid
      FormulationA 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.
      Hill FormulaC₁₅H₁₀BrN₃O
      Chemical formulaC₁₅H₁₀BrN₃O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGSK-3β
      Primary Target IC<sub>50</sub>18 nM for GSK-3&beta
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36/37/39

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      191501

      References

      Reference overview
      Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-September-2012 JSW
      DescriptionA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.
      FormLiquid
      FormulationA 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number676596-65-9
      Chemical formulaC₁₅H₁₀BrN₃O
      Structure formulaStructure formula
      Purity≥94% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.