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412520 Iron Chelator, Dp44mT - CAS 152095-12-0 - Calbiochem

Prevents the aggressive growth of M109 lung carcinoma in mice without affecting body weight. Shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.

Iron Chelator, Dp44mT - CAS 152095-12-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,2ʹ-Dipyridyl-N,N-dimethylsemicarbazone

412520
  
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      Overview

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      This product has been discontinued.





      A cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that displays potent and selective antiproliferative properties in neoplastic cells (IC50 ≤ 0.06 µM in SK-N-MC, SK-Mel-28 and MCF-7 cells) and minimally affects normal cells (IC50 > 25 µM in MRC-5). Prevents the aggressive growth of M109 lung carcinoma in mice without affecting body weight. Shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.
      Catalogue Number412520
      Brand Family Calbiochem®
      Synonyms2,2ʹ-Dipyridyl-N,N-dimethylsemicarbazone
      References
      ReferencesYuan, J., et al. 2004. Blood 104, 1450.
      Product Information
      CAS number152095-12-0
      FormYellow solid
      Hill FormulaC₁₄H₁₅N₅S
      Chemical formulaC₁₄H₁₅N₅S
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      412520 0

      Documentation

      Iron Chelator, Dp44mT - CAS 152095-12-0 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Iron Chelator, Dp44mT - CAS 152095-12-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      412520

      References

      Reference overview
      Yuan, J., et al. 2004. Blood 104, 1450.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms2,2ʹ-Dipyridyl-N,N-dimethylsemicarbazone
      DescriptionA cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that exhibits potent and selective anti-proliferative properties in neoplastic cells (IC50 ≤60 nM in SK-N-MC, SK-Mel-28 and MCF-7 cells) with minimal effects on normal cells (IC50 >25 µM in MRC-5). Prevents the aggressive growth of M109 lung carcinoma in mice without affecting their body weight. Its autitumor effects are believed to be linked to activation of caspase-3. Shown to mobilize cellular iron effectively, generating ROS that leads to apoptosis.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number152095-12-0
      Chemical formulaC₁₄H₁₅N₅S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesYuan, J., et al. 2004. Blood 104, 1450.