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482100 L-NIL, Dihydrochloride - Calbiochem

A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase than for the rat brain constitutive enzyme

L-NIL, Dihydrochloride - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-N⁶-(1-Iminoethyl)lysine, DiHCl

Primary Target: iNOS
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482100
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₈H₁₇N₃O₂ · 2HCl
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase (IC50 = 3.3 µM) than for the rat brain constitutive enzyme (IC50 = 92 µM). Exhibits about 10-fold greater inhibitory potency than NG-Monomethyl-L-arginine (L-NMMA; Cat. No. 475886) in inhibiting γ-interferon-induced NO2- production (IC50 = 460 nM).
      Catalogue Number482100
      Brand Family Calbiochem®
      SynonymsL-N⁶-(1-Iminoethyl)lysine, DiHCl
      References
      ReferencesMoore, W.M., et al. 1996. J. Med. Chem. 39, 669.
      Connor, J.R., et al. 1995. Eur. J. Pharmacol. 273, 15.
      Stenger, S., et al. 1995. Eur. J. Pharmacol. 294, 703.
      Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
      Stuehr, D.J., and Griffith, O.W. 1992. Adv. Enzymol. 65, 287.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₇N₃O₂ · 2HCl
      Chemical formulaC₈H₁₇N₃O₂ · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetiNOS
      Primary Target IC<sub>50</sub>3.3 µM against inducible nitric oxide synthase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 3 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      482100 0

      Documentation

      L-NIL, Dihydrochloride - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      L-NIL, Dihydrochloride - Calbiochem Certificates of Analysis

      TitleLot Number
      482100

      References

      Reference overview
      Moore, W.M., et al. 1996. J. Med. Chem. 39, 669.
      Connor, J.R., et al. 1995. Eur. J. Pharmacol. 273, 15.
      Stenger, S., et al. 1995. Eur. J. Pharmacol. 294, 703.
      Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
      Stuehr, D.J., and Griffith, O.W. 1992. Adv. Enzymol. 65, 287.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsL-N⁶-(1-Iminoethyl)lysine, DiHCl
      DescriptionA potent and selective inhibitor of inducible nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase (IC50 = 3.3 µM) than for the rat brain constitutive enzyme (IC50 = 92 µM). Exhibits about 10-fold greater inhibitory potency than NG-monomethyl-L-arginine in inhibiting γ-interferon-induced NO2· production (IC50 = 460 nM)
      FormWhite solid
      Chemical formulaC₈H₁₇N₃O₂ · 2HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (100 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 3 months at 4°C.
      Toxicity Irritant
      ReferencesMoore, W.M., et al. 1996. J. Med. Chem. 39, 669.
      Connor, J.R., et al. 1995. Eur. J. Pharmacol. 273, 15.
      Stenger, S., et al. 1995. Eur. J. Pharmacol. 294, 703.
      Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
      Stuehr, D.J., and Griffith, O.W. 1992. Adv. Enzymol. 65, 287.