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444237 MMP-8 Inhibitor I - CAS 236403-25-1 - Calbiochem

The MMP-8 Inhibitor I, also referenced under CAS 236403-25-1, controls the biological activity of MMP-8. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MMP-8 Inhibitor I - CAS 236403-25-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (3R)-(+)-[2-(4-Methoxybenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-hydroxamate]

Primary Target: MMP-8
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      236403-25-1C₁₇H₁₈N₂O₅S
      Description
      Overview

      This product has been discontinued.



      A potent and cell-permeable inhibitor of MMP-8 (IC50 = 4 nM).
      Catalogue Number444237
      Brand Family Calbiochem®
      Synonyms(3R)-(+)-[2-(4-Methoxybenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-hydroxamate]
      References
      ReferencesPrager, G.W., et al. 2004. Blood 103, 955.
      Matter, H., et al. 1999. J. Med. Chem. 42, 1908.
      Product Information
      CAS number236403-25-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₇H₁₈N₂O₅S
      Chemical formulaC₁₇H₁₈N₂O₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-8
      Primary Target IC<sub>50</sub>4 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      444237 0

      Documentation

      MMP-8 Inhibitor I - CAS 236403-25-1 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      MMP-8 Inhibitor I - CAS 236403-25-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      444237

      References

      Reference overview
      Prager, G.W., et al. 2004. Blood 103, 955.
      Matter, H., et al. 1999. J. Med. Chem. 42, 1908.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2011 RFH
      Synonyms(3R)-(+)-[2-(4-Methoxybenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-hydroxamate]
      DescriptionA cell-permeable, potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 4 nM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number236403-25-1
      Chemical formulaC₁₇H₁₈N₂O₅S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPrager, G.W., et al. 2004. Blood 103, 955.
      Matter, H., et al. 1999. J. Med. Chem. 42, 1908.