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479975 NDGA - CAS 500-38-9 - Calbiochem

A cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC₅₀ = 200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC₅₀ = 100 µM).

NDGA - CAS 500-38-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nordihydroguaiaretic Acid

Primary Target: LOX-5
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      500-38-9C₁₈H₂₂O₄
      Description
      OverviewA cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC50 = 200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC50 = 100 µM). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss/3T3 cells. A powerful hydroxy radical quencher.
      Catalogue Number479975
      Brand Family Calbiochem®
      SynonymsNordihydroguaiaretic Acid
      References
      ReferencesDomin, J., et al. 1994. J. Biol. Chem. 269, 8260.
      Goodman, Y., et al. 1994. Brain Res. 654, 171.
      Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
      Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
      Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.
      Product Information
      CAS number500-38-9
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₁₈H₂₂O₄
      Chemical formulaC₁₈H₂₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLOX-5
      Primary Target IC<sub>50</sub>200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUX1750000
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      479975 0

      Documentation

      NDGA - CAS 500-38-9 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      NDGA - CAS 500-38-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      479975

      References

      Reference overview
      Domin, J., et al. 1994. J. Biol. Chem. 269, 8260.
      Goodman, Y., et al. 1994. Brain Res. 654, 171.
      Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
      Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
      Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 JSW
      SynonymsNordihydroguaiaretic Acid
      DescriptionA cell-permeable, antioxidant and a selective lipoxygenase (LO) inhibitor (IC50 = 200 nM, 30 µM, and 30 µM for 5-LO, 12-LO, and 15-LO, respectively) over cyclooxygenase (IC50 = 100 µM). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss 3T3 cells.
      FormCrystalline solid
      CAS number500-38-9
      RTECSUX1750000
      Chemical formulaC₁₈H₂₂O₄
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 6693
      ReferencesDomin, J., et al. 1994. J. Biol. Chem. 269, 8260.
      Goodman, Y., et al. 1994. Brain Res. 654, 171.
      Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
      Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
      Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.