Millipore Sigma Vibrant Logo

506132 Pifithrin-α - CAS 63208-82-2 - Calbiochem

A cell-permeable chemical inhibitor of p53.

Pifithrin-α - CAS 63208-82-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr

Primary Target: PS3
View Products on Sigmaaldrich.com
506132
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
63208-82-2C₁₆H₁₈N₂OS·HBr

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
506132-10MG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Ampul plastik 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      506132-5MG
      Retrieving availability...
      —
      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Ampul plastik 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          Description
          OverviewA cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.
          Catalogue Number506132
          Brand Family Calbiochem®
          Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
          References
          ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
          Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
          Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
          Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
          Ferber, D. 1999. Science 285, 1651.
          Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
          Komarov, P.G., et al. 1999. Science 285, 1733.
          Product Information
          CAS number63208-82-2
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₆H₁₈N₂OS·HBr
          Chemical formulaC₁₆H₁₈N₂OS·HBr
          HS Code2934 20 90
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPS3
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          506132-10MG 04055977199499
          506132-5MG 04055977199505

          Documentation

          Pifithrin-α - CAS 63208-82-2 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Pifithrin-α - CAS 63208-82-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          506132

          References

          Reference overview
          Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
          Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
          Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
          Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
          Ferber, D. 1999. Science 285, 1651.
          Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
          Komarov, P.G., et al. 1999. Science 285, 1733.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
          DescriptionA reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against β-amyloid and glutamate-induced apoptosis.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number63208-82-2
          Chemical formulaC₁₆H₁₈N₂OS·HBr
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
          Toxicity Standard Handling
          ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
          Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
          Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
          Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
          Ferber, D. 1999. Science 285, 1651.
          Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
          Komarov, P.G., et al. 1999. Science 285, 1733.