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534347 hCNT2 Inhibitor

Potently inhibits hCNT2-mediated Na+-dependent inosine uptake (IC₅₀ = 640 nM in COS-7 cells).

hCNT2 Inhibitor MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor

Primary Target: hCNT2
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₃H₂₄N₆O₄
      Description
      Overview

      This product has been discontinued.



      An aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na+-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC50 of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

      Catalogue Number534347
      Brand Family Calbiochem®
      Synonyms8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
      DescriptionhCNT2 Inhibitor
      References
      ReferencesTatani, K., et al. 2015. ACS Med. Chem. Lett. 6, 244.
      Product Information
      FormPale yellow solid
      Hill FormulaC₂₃H₂₄N₆O₄
      Chemical formulaC₂₃H₂₄N₆O₄
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargethCNT2
      Primary Target IC<sub>50</sub>640 nM in COS-7 cells
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      534347 0

      Documentation

      hCNT2 Inhibitor MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Tatani, K., et al. 2015. ACS Med. Chem. Lett. 6, 244.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-June-2016 JSW
      Synonyms8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
      DescriptionAn aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na+-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC50 of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₂₄N₆O₄
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTatani, K., et al. 2015. ACS Med. Chem. Lett. 6, 244.