203391 Sigma-Aldrich(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem
The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
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Overview
Replacement Information |
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Key Spec Table
CAS # | Empirical Formula |
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856925-71-8 | C₁₈H₁₆N₂O₂ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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203391-1MG | Plastic ampoule | 1 mg |
Description | |
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Overview | The active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity towards ATPase (IC50 = ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM). |
Catalogue Number | 203391 |
Brand Family | Calbiochem® |
Product Information | |
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CAS number | 856925-71-8 |
ATP Competitive | N |
Form | Yellow solid |
Hill Formula | C₁₈H₁₆N₂O₂ |
Chemical formula | C₁₈H₁₆N₂O₂ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | ATPase |
Primary Target IC<sub>50</sub> | 2 µM |
Purity | ≥98% by Chiral HPLC |
Physicochemical Information | |
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Cell permeable | N |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Transport Information |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
203391-1MG | 04055977221275 |
Documentation
(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem SDS
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(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem Certificates of Analysis
Title | Lot Number |
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203391 |
References
Reference overview |
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Eddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865. Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472. Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557. Straight, A.F., et al. 2003. Science 299, 1743. |