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164603 3-Nitropropionic acid - CAS 504-88-1 - Calbiochem

A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA

164603
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₃H₅NO₄504-88-1

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      Description
      OverviewA cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
      Catalogue Number164603
      Brand Family Calbiochem®
      Synonyms3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
      References
      ReferencesBeal, M., et al. 1993, J. Neurosci. 13, 4181.
      Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
      Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
      Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
      Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.
      Product Information
      CAS number504-88-1
      FormLight yellow powder
      Hill FormulaC₃H₅NO₄
      Chemical formulaC₃H₅NO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25-36/37/38

      Toxic if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      3-Nitropropionic acid - CAS 504-88-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      164603

      References

      Reference overview
      Beal, M., et al. 1993, J. Neurosci. 13, 4181.
      Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
      Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
      Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
      Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-June-2012 JSW
      Synonyms3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
      DescriptionA cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
      FormLight yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number504-88-1
      Chemical formulaC₃H₅NO₄
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO or Ethanol (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesBeal, M., et al. 1993, J. Neurosci. 13, 4181.
      Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
      Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
      Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
      Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.