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164603 3-Nitropropionic acid - CAS 504-88-1 - Calbiochem

A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA

164603
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
504-88-1C₃H₅NO₄

Products

Catalogue NumberPackaging Qty/Pack
164603-50MG Glass bottle 50 mg
Description
OverviewA cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
Catalogue Number164603
Brand Family Calbiochem®
Synonyms3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
References
ReferencesBeal, M., et al. 1993, J. Neurosci. 13, 4181.
Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.
Product Information
CAS number504-88-1
FormLight yellow powder
Hill FormulaC₃H₅NO₄
Chemical formulaC₃H₅NO₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 25-36/37/38

Toxic if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

3-Nitropropionic acid - CAS 504-88-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

3-Nitropropionic acid - CAS 504-88-1 - Calbiochem Certificates of Analysis

TitleLot Number
164603

References

Reference overview
Beal, M., et al. 1993, J. Neurosci. 13, 4181.
Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-June-2012 JSW
Synonyms3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
DescriptionA cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
FormLight yellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number504-88-1
Chemical formulaC₃H₅NO₄
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO or Ethanol (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesBeal, M., et al. 1993, J. Neurosci. 13, 4181.
Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.